PHYSICAL EVALUATION OF PCL-AGNPS BIOCOMPOSITES AS GUIDED TISSUE REGENERATION MEMBRANE
DOI:
https://doi.org/10.11113/jt.v82.13294Keywords:
Guided tissue regeneration, polycaprolactone, AgNPs, electrospinningAbstract
Dental and mouth problems in Indonesia during 2007 to 2013 reportedly increased from 23.2% to 25.9% with the projection 65.275 million people with cases of periodontitis reaching 42.8%. One of clinical treatment of periodontitis is by using Guided Tissue Regeneration (GTR) method. This research was conducted to synthesize GTR membrane from Polycaprolactone (PCL) which is composed with AgNPs of Aloe vera biosynthesis product using electrospinning instrument. GTR membranes were synthesized by forming ratio of acetone and AgNPs which was obtained by mixing 30% Aloe vera extract with AgNO3 solution where AgNPs had been characterized previously using XRD and PSA. In this study the comparison of solvents done as 100/0 (control), 90/10, 80/20, and 70/30 (v/v). Obtained GTR membranes are characterized by Scanning Electron Microscope and tensile strength characterization. From the analysis results known the best composition of PCL-AgNPs biocomposite as GTR membrane was found on the variable with ratio 70/30 (v/v) with fiber size 111,6 ± 22 nm, UTS value equal to 4,37 MPa with elongation equal to 204%. Based on the results of characterization, it showed that biocomposites PCL-AgNPs Aloe vera biosynthesis products have good potential as a guided tissue regeneration membrane.
References
Costalonga, M., Herzberg, M. C. 2014. The Oral Microbiome and the Immunobiology of Periodontal Disease and Caries. Immunol Lett. 162: 22-38. Doi:10.1016/j.imlet.2014.08.017.
Stewart, R., West, M. 2016. Increasing Evidence for an Association between Periodontitis and Cardiovascular Disease. Circulation. 133(6): 549-51. Doi: 10.1161/CIRCULATIONAHA.115.020869. Epub 2016 Jan 13.
RISKESDAS. 2013. https://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.115.020869?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed.
Carter, P., Rahman, S. M., Bhattarai, N. 2016. Facile Fabrication of Aloe Vera Containing PCL Nanofibers for Barrier Membrane Application. J. of Biomaterial Science, Polymer Edition 2016. 27: 692-708. Doi: 10.1080/09205063.2016.1152857.
Campoccia, D., Montanaro, L., Arciola, C. R. 2013. A Review of the Biomaterials Technologies for Infection-resistant Surfaces. Biomaterials [Internet]. 34(34): 8533–54. Available from: http://dx.doi.org/10.1016/j.biomaterials.2013.07.089.
Larsson, L., Decker, A. M., Nibali, L., Pilipchuk, S. P., Berglundh, T., Giannobile, W. V. 2016. Regenerative Medicine for Periodontal and Peri-implant Diseases. J Dent Res. 95(3): 255-66. Doi: 10.1177/0022034515618887. Epub 2015 Nov 25.
Maissa Jafari, Zahrasadat Paknejad, Maryam Rezai Rad, Saeed Reza Motamedian,Mohammad Jafar Eghbal, Nasser Nadjmi, Arash Khojasteh. 2017. Polymeric Scaffolds in Tissue Engineering: A Literature Review. Journal of Biomedical Materials Research B: Applied Biomaterials. 105B(2): 431-459.
Franci, G., Falanga, A., Galdiero, S., Palomba, L., Rai, M., Morelli, G., et al. 2015. Silver Nanoparticles as Potential Antibacterial Agents. Molecules. 20(5): 8856-74.
Vargas-reus, M. A., Memarzadeh, K., Huang, J., Ren, G. G., Allaker, R. P. 2012. Antimicrobial Activity of Nanoparticulate Metal Oxides against Peri-implantitis Pathogens. Int J Antimicrob Agents [Internet]. 40(2): 135-9. Available from: http://dx.doi.org/10.1016/j.ijantimicag.2012.04.012.
Yixis, Zhang, Dapeng, Y. 2010. Synergetic Antibacterial Effects of Silver Nanoparticles@Aloe Vera Prepared via a Green Method. Nano Biomed Eng. 2(4): 252-7.
Naheed Ahmad, Seema Sharma, Radheshyam Rai. 2012. Rapid Green Synthesis of Silver and Gold Nanoparticles using Peels of Punica granatum. Adv. Mat. Lett. 3(5): 376-380. DOI: 10.5185/amlett.2012.6357.
Moosa, A. A., Ridha, A. M., Al-kaser, M. 2015. Process Parameters for Green Synthesis of Silver Nanoparticles using Leaves Extract of Aloe Vera Plant. Int. J. of Multidisciplinary and Current Research. 3(3): 966-75.
Korani, M., Rezayat, S. M., Gilani, K., Arbabi Bidgoli, S., Adeli, S. 2011. Acute and Subchronic Dermal Toxicity of Nanosilver in Guinea Pig. Int J Nanomedicine. 6: 855-62.
Qin, G., Tang, S., Li, S., Lu, H., Wang, Y., Zhao, P., Li, B., Zhang, J., Peng, L. 2017. Toxicological Evaluation of Silver Nanoparticles and Silver Nitrate in Rats Following 28 Days of Repeated Oral Exposure. Environ Toxicol. 32(2): 609-618. Doi: 10.1002/tox.22263.
Shreya Medda, Amita Hajra, Uttiya Dey, Paulomi Bose, Naba Kumar Mondal. 2015. Biosynthesis of Silver Nanoparticles from Aloe Vera Leaf Extract and Antifungal Activity against Rhizopus sp. and Aspergillus sp. Applied Nanoscience. 5(7): 875-880.
Hadrup, N., Lam, H. R. 2014. Oral Toxicity of Silver Ions, Silver Nanoparticles and Colloidal Silver–A Review. Regul Toxico Pharmacol [Internet]. 68(1): 1-7. Available from: http://dx.doi.org/10.1016/j.yrtph.2013.11.002.
Shekh Rahman, Princeton Carter, and Narayan Bhattarai 2017. Aloe Vera for Tissue Engineering Applications. J Funct Biomater. 8(1): 6. Doi: 10.3390/jfb8010006.
Hinojos-Márquez, E. A., López-Esparza, J., Espinosa-Cristóbal, L. F., Donohue-Cornejo, A., Reyes-López, S. Y. 2016. Antimicrobial Activity of Silver Nanoparticles Inpolycaprolactone nanofibers against Gram-positive and Negative Bacteria. Ind Eng Chem Res. http://dx.doi.org/10.1021/acs.iecr.6b02300.
Bottino, M. C., Thomas, V., Schmidt, G., Vohra, Y. K., Chu T. G., Kowolik, M. J., et al. 2012. Recent Advances in the Development of GTR/GBR Membranes for Periodontal Regeneration—A Materials Perspective. Dent Mater [Internet]. 28(7): 703-21. Available from: http://dx.doi.org/10.1016/j.dental.2012.04.022.
Li, Z., Wang, C. 2013. One Dimensional Nanostructures : Electrospinning Technique and Unique Nanofibers. Springer New York Heidelberg Dordrecht London.
Sergio Torres-Giner, Rocıo Perez-Masi a, Jose M. Lagaron, 2016. A Review on Electrospun Polymer Nanostructures as Advanced Bioactive Platforms. Polymer Engineering and Science. 56(5): 500-527. Doi: 10.1002/pen.
Mitchell, G., Grande, M. 2015. Electrospinning : Principles, Practice, and Possibilities. Tang, B. Z., Mitchell, G. R. Editors. Cambridge, UK: The Royal Society of Chemistry.
Pazos-ortiz, E., Roque-ruiz, J. H., Hinojos-márquez, E. A., López-esparza, J., Donohué-cornejo, A., Cuevas-gonzález, J. C. et al. 2017. Dose-dependent Antimicrobial Activity of Silver Nanoparticles on Polycaprolactone Fibers against Gram-positive and Gram-negative Bacteria. Journal of Nanomaterials. 2017: 1-9.
Cramariuc, B., Cramariuc, R., Scarlet, R., Rozemarie, L., Lupu, I. G. 2013. Fiber Diameter in Electrospinning Process. J Electrostat [Internet]. 71(3): 189-98. Available from: http://dx.doi.org/10.1016/j.elstat.2012.12.018.
Zhang, C-L., Yu, S-H. 2014. Nanoparticles Meet Electrospinning : Recent Advances and Future Prospects. Chem Soc Rev. 43(13): 4423-48. Doi: 10.1039/c3cs60426h.
Anindyajati, A., Boughton, P., Ruys, A. 2015. The Effect of Rotating Collector Design on Tensile Properties and Morphology of Electrospun Polycaprolactone Fibres. MATEC Web of Conference. 27(02002): 1-6. Doi: 10.1051/matecconf/20152702002.
Thomas, R., Soumya, K. R., Mathew, J., Radhakrishnan, E. K. 2015. Electrospun Polycaprolactone Membrane Incorporated with Biosynthesized Silver Nanoparticles as Effective Wound Dressing Material. Appl Biochem Biotchnology. 176: 2213-24.
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