LIPOSOME AS TRANSDERMAL CARRIER FOR LABISIA PUMILA AND FICUS DELTOIDEA WATER EXTRACTS
DOI:
https://doi.org/10.11113/jt.v79.10205Keywords:
Labisia pumila, Ficus deltoidea, liposomes, transdermal delivery, cosmeticAbstract
In this study, liposome has been investigated as the potential transdermal carrier for Labisia pumila (Lp) and Ficus deltoidea (Fd). The encapsulation efficiency, zeta potential, particle size and transdermal transport properties of the herbal extracts loaded liposomes were determined to characterize the delivery system. The entrapment efficiency for Lipo-Lp and Lipo-Fd were 35.47 ± 2.71% and 31.23 ± 7.65%, respectively. The average diameter were153.35nm and 131.9nm, respectively and the zeta potential were -47.2 and -46.8, respectively. The permeability and partition coefficient (K) of Lipo-Lp were 1.31cm h-1 and 10.05, respectively and the permeability and partition coefficient (K) of Lipo-Fd were 1.28cm h-1 and 7.62, respectively. Labisia pumila and Ficus deltoidea loaded liposomes showed better transdermal permeation compared to un-encapsulated Labisia pumila and Ficus deltoidea indicative of potential actives herbal cosmetic formulations.
References
Trommer, H., and Neubert, R. H. H. 2006. Overcoming the Stratum Corneum; the Modulation of Skin Penetration. Skin Pharmacology and Physiology. 19: 106-121.
Phikunthong, K., Varissaporn, M., & Choochart, W. 2011. The Potential Use of Niosomes for Encapsulation of Nisin and EDTA and their Antibacterial Enhancement. Food Research International. 605-622.
El Maghraby, G. M., Barryc, B. W. and Williams, A. C. 2008. Liposomes and Skin: From Drug Delivery to Model Membranes. European Journal of Pharmaceutical Sciences. 34(4-5): 203-222.
Juanjuan, L. and Gan, H. 2007. Advances in Studies of Phospholipids as Carriers in Skin Topical Application. Journal of Nanjing Medical University. 21(6): 349-353.
Chua, L. S., Lee, S. Y., Norhanisah, A. and Mohamad Roji, S. 2012. Review on Labisia pumila (Kacip Fatimah): Bioactive Phytochemicals and Skin Collagen Synthesis Promoting Herb. Fitoterapia. 83: 1322-1335.
Choi, H. K., Kim, D. H., Kim, J. W. Ngadiran, S., Sarmidi, M. R. and Park, C. S. 2010. Labisia pumila Extract Protects Skin Cells from Photoaging Caused by UVB Irradiation. Journal of Bioscience and Bioengineering. 109(3): 291-296.
Oh, M. J., Hamid, M. A., Ngadiran, S., Seo, Y. K., Sarmidi, M. R., and Park, C. S. 2011. Ficus Deltoidea (Mas cotek) Extract Exerted Anti-melanogenic Activity by Preventing Tyrosinase Activity in Vitro Aand by Suppressing Tyrosinase Gene Expression in B16F1 Melanoma Cells. Archive of Dermatology Research. 161-170.
Hamidun, B., Noriha, M. A., Siti Noraini, B., Syarul Nataqain, B. and Normah, M. N. 2014. Ficus deltoidea Jack: A Review on Its Phytochemical and Pharmacological Importance. Evidence-Based Complementary and Alternative Medicine. 1-8.
Rosnani, H., Choi, H. K., Sarmidi, M. R. and Park, C.S. 2013. Protective Effects of a Ficus deltoidea (Mas cotek) Extract against UVB-Induced Photoaging in Skin Cells. Biotechnology and Bioprocess Engineering. 18: 185-193.
Ahmed. T. and El-Say, K. 2016. Transdermal Film-loaded Finasteride Microplates to Enhance Drug Skin Permeation: Two-step Optimisation Study. European Journal of Pharmaceutical Sciences. 88: 246-256.
Al-Suwayeh, S. 2003. Transdermal Delivery of Isradipine Through Excised Rabbit Skin: Effect of the Vehicle and Drug Concentration. Saudi Pharmaceutical Journal. 11(1-2): 46-51.
Nur Zatul Iradah, R., Azila, A. A., Mohamad Roji, S. and Ramlan, A. A. 2010. Antioxidant Coated Liposomes as the Delivery System for Papain Based Natural Cosmetics. IEEE Conference Publication-International Conference on Enabling Science and Nanotechnology (ESciNano).
Kopermsub, P., Mayen, V. and Warin, C. 2011. Potential Use of Niosomes for Encapsulation of Nisin and EDTA and Their Antibacterial Activity Enhancement. Food Research International. 44(2): 605-612.
Nitipong, J., Nongnuch, R., Kamonwan, R. and Teeraporn, K. 2014. Effect of Combined Antioxidants and Packing on Lipid Oxidation of Salted Dried Snakehead Fish (Channa Striata) During Refrigerated Storage. International Food Research Journal. 21(1): 91-99.
Barenholz, Y. and Cromellin, D. J. A. 1994. Encyclopedia of Pharmaceutical Technology. Ed. Swarbick, J. Marcel Dekker, New York.
Costa, C. A. M. and Moraes, A. M. 2003. Encapsulation of 5-fluorourcil in Liposomes for Topical Administration. Acta Science Technology. 25: 53-56.
Xu, X. Costa, A. and Burgess, D. J. 2012. Protein Encapsulation in Unilamellar Liposomes: High Encapsulation Efficiency and a Novel Technique To Assess Lipid – Protein Interaction. Pharmaceutical Research. 29(7): 1919-1931.
Ogiso, T., Yamaguchi, T., Iwaki, M., Tanino, T. and Miyaki, Y. 2001. Effect of Positively and Negatively Charge Liposomes on Skin Permeation Drugs. Journal of Drug Targeting. 9(1): 49-59.
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