ENTRAPMENT OF FREE CELLS WITHIN ELECTROSPUN NANOFIBERS: MINI REVIEW ON PARAMETERS INFLUENCING NANOFIBERS CHARACTERISTICS AND CELLS VIABILITY

Aiman Farhana Azaddin; Roshanida A. Rahman; Mazura Jusoh; Juhana Jaafar; Norzita Ngadi; Nor Hasmaliana Abdul Manas

doi:10.11113/jurnalteknologi.v82.14929

Authors

Aiman Farhana Azaddin School of Chemical and Energy Engineering, Faculty of Engineering, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia
Roshanida A. Rahman School of Chemical and Energy Engineering, Faculty of Engineering, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia
Mazura Jusoh School of Chemical and Energy Engineering, Faculty of Engineering, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia
Juhana Jaafar School of Chemical and Energy Engineering, Faculty of Engineering, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia
Norzita Ngadi School of Chemical and Energy Engineering, Faculty of Engineering, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia
Nor Hasmaliana Abdul Manas School of Chemical and Energy Engineering, Faculty of Engineering, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia

DOI:

https://doi.org/10.11113/jurnalteknologi.v82.14929

Keywords:

Entrapment, immobilization, electrospinning, nanofibers, viability

Abstract

Nanotechnology is a growing technology that has been recognized as vital and scientific with bioprocess development especially in dealing with usage of free cells. Limitations such as low bioavailability, storage instability and low substrate inhibition bound the application of free cells in various field thus leading researchers into focusing more on free cells immobilization system. With the increasing knowledge in nanomaterials fabrication techniques, the immobilization of free cells through entrapment approach in highly porous and the high surface area of nanofibers is becoming an interesting subject to be highlighted. The production of free cells entrapped in nanofibers via electrospinning in terms of quality and quantity is highly affected by the electrospinning operating parameters including solution formulation, ambient conditions, operating conditions of electrospinning machine and types of materials used. Hence, this review paper will provide an overview of the operating conditions involved in electrospinning of cells through entrapment process which affect the characteristics of the electrospun nanofibers produced and the viability or growth of cells when entrapped in the electrospun nanofibers mats.

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