ANTI-QUORUM SENSING AND ANTIBIOTIC ENHANCEMENT OF ALLYLPYROCATECHOL AND METHYL GALLATE

Authors

  • Carine S. S. Lim Faculty of Applied Sciences, UCSI University, Cheras 56000, Kuala Lumpur, Malaysia
  • Eric W. C. Chan UCSI University, Cheras, Kuala Lumpur
  • C. W. Wong Faculty of Applied Sciences, UCSI University, Cheras 56000, Kuala Lumpur, Malaysia https://orcid.org/0000-0003-0469-2887
  • Joash B. L. Tan School of Science, Monash University Malaysia, Bandar Sunway 47500, Selangor, Malaysia
  • V. S. Anggraeni Faculty of Applied Sciences, UCSI University, Cheras 56000, Kuala Lumpur, Malaysia https://orcid.org/0000-0002-5098-287X
  • Z. J. Loong Faculty of Applied Sciences, UCSI University, Cheras 56000, Kuala Lumpur, Malaysia
  • Y. K. Teo School of Science, Monash University Malaysia, Bandar Sunway 47500, Selangor, Malaysia https://orcid.org/0000-0001-5025-9561

DOI:

https://doi.org/10.11113/jurnalteknologi.v83.15146

Keywords:

Allylpyrocatechol, Piper betle, methyl gallate, Anacardium occidentale, antibiotic enhancement, quorum sensing inhibition

Abstract

In this study, the antibiotic enhancement and quorum sensing (QS) inhibition of allylpyrocatechol (APC) and methyl gallate (MG) isolated from leaves of Piper betle (betel) and leaf shoots of Anacardium occidentale (cashew), respectively, were compared. When applied with streptomycin and tested against Staphylococcus aureus and Pseudomonas aeruginosa, the effect of APC was additive while that of MG was synergistic. In terms of QS inhibition against Chromobacterium violaceum, both compounds were equally effective with violacein inhibition observed at concentrations of 60 μg/mL. We successfully increased the purity of APC in the methanol betel leaf extract from 13.2% to 31.5% w/w through solvent partitioning. This study is the first to document the anti-QS activity of APC, which is comparable to that of MG. 

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Published

2021-04-06

Issue

Vol. 83 No. 3: May 2021

Section

Science and Engineering

License

Copyright of articles that appear in Jurnal Teknologi belongs exclusively to Penerbit Universiti Teknologi Malaysia (Penerbit UTM Press). This copyright covers the rights to reproduce the article, including reprints, electronic reproductions, or any other reproductions of similar nature.

How to Cite

ANTI-QUORUM SENSING AND ANTIBIOTIC ENHANCEMENT OF ALLYLPYROCATECHOL AND METHYL GALLATE . (2021). Jurnal Teknologi (Sciences & Engineering), 83(3), 101-106. https://doi.org/10.11113/jurnalteknologi.v83.15146