CELL IMMOBILIZATION FOR CYCLODEXTRIN PRODUCTION: MINI REVIEW

Authors

  • Nurul Nabila Huda Baharudin Department of Chemical and Process Engineering Technology, College of Engineering, UMP, Lebuhraya Tun Razak, 26300 Gambang, Pahang, Malaysia https://orcid.org/0000-0001-9533-3454
  • Rohaida Che Man Department of Chemical and Process Engineering Technology, College of Engineering, UMP, Lebuhraya Tun Razak, 26300 Gambang, Pahang, Malaysia https://orcid.org/0000-0001-5654-534X
  • Nor Hasmaliana Abdul Manas ᵇSchool of Chemical and Energy Engineering, Faculty of Engineering, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia ᶜInstitute of Bioproduct Development, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia https://orcid.org/0000-0001-6758-9057
  • Rabi'atul Adawiyah Ahmad Faculty of Health and Life Sciences, INTI International University, Persiaran Perdana BBN Putra Nilai, 71800 Nilai, Negeri Sembilan, Malaysia
  • Nur Nadia Mohd Zakaria Department of Chemical and Process Engineering Technology, College of Engineering, UMP, Lebuhraya Tun Razak, 26300 Gambang, Pahang, Malaysia https://orcid.org/0000-0002-3704-1442

DOI:

https://doi.org/10.11113/jurnalteknologi.v85.18859

Keywords:

Cell immobilization, cyclodextrin, cyclodextrin glucanotransferase, immobilization supports, immobilization techniques

Abstract

Cell immobilization has been applied in various industries, including chemical manufacturing, food, pharmaceutical, and textile. Recently, innovations in cell immobilization techniques and support materials have been put forward for application in high value-added chemical biosynthesis, such as cyclodextrin (CD). The techniques, support materials, and process parameters of cell immobilization play important roles in achieving high CD yield. This review should help one choose the correct cell immobilization technique and support for a CD biosynthesis setup. Previously, CD biosynthesis utilized free cells, even though they present difficulties such as the low product yield, cell lysis, unstable plasmid, and non-reusable cells. This review highlights how the problems that arise from free-cell bioreactors could be mitigated by cell immobilization. The process conditions of cell immobilization for CD production are also presented.

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Published

2023-02-23

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Vol. 85 No. 2: March 2023

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Science and Engineering

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CELL IMMOBILIZATION FOR CYCLODEXTRIN PRODUCTION: MINI REVIEW. (2023). Jurnal Teknologi, 85(2), 111-120. https://doi.org/10.11113/jurnalteknologi.v85.18859