ZINGIBER ZERUMBET: PHARMACOLOGICAL VALUES OF ZERUMBONE AND THE EXTRACTION TECHNOLOGY EVOLUTION
DOI:
https://doi.org/10.11113/jurnalteknologi.v85.18913Keywords:
Zingiber zerumbet, rhizome, zerumbone, pharmacological value, extraction technologyAbstract
Over the past eight decades, numerous research has been conducted on the extraction of Zingiber zerumbet rhizome. The mini-review includes information on the pharmacological properties of zerumbone extracted from Z. zerumbet rhizome and the extraction methods conducted over the previous 80 years. Zerumbone is recognised as having a proven pharmacological effect and is a significant medicinal component used to treat various ailments. The pharmacological values are stated based on the research findings. The extraction method and technology are essential to extract zerumbone. Thus, the review helps the reader keep up with the history of each technique or technology used in extracting zerumbone from Z. zerumbet rhizome, starting with conventional technology and moving toward advanced technology.
References
A. Y. Koga, F. L. Beltrame, and A. V. Pereiraz. 2016. Several Aspects of Zingiber zerumbet: A Review. Rev. Bras. Farmacogn. 26(3): 385-391. Doi: 10.1016/j.bjp.2016.01.006.
H. S. Rahman et al. 2014. Biomedical Properties of a Natural Dietary Plant Metabolite, Zerumbone, in Cancer Therapy and Chemoprevention Trials. Biomed Res. Int. 1-20. Doi: 10.1155/2014/920742.
N. J. Yob, S. M. Jofrry, M. M. R. M. M. Affandi, L. K. Teh, M. Z. Salleh, and Z. A. Zakaria. 2011. Zingiber zerumbet (L.) Smith: A Review of Its Ethnomedicinal, Chemical, and Pharmacological Uses. Evidence-based Complement. Altern. Med. 1-12. Doi: 10.1155/2011/543216.
K. K. Rout, S. K. Mishra, and J. Sherma. 2009. Development and Validation of an HPTLC Method for Analysis of Zerumbone, the Anticancer Marker from Zingiber Zerumbet. Acta Chromatogr. 21(3): 443-452. Doi: 10.1556/AChrom.21.2009.3.8.
M. Tian, X. Wu, Y. Hong, H. Wang, G. Deng, and Y. Zhou. 2020. Comparison of Chemical Composition and Bioactivities of Essential Oils from Fresh and Dry Rhizomes of Zingiber zerumbet (L.) Smith. Biomed Res. Int. 1-9. Doi: 10.1155/2020/9641284.
W. Widyastiwi and M. Roseno. 2022. Anxiolytic Activity of Ethanolic Extract of Three Species of Indonesian Lempuyang (Zingiber zerumbet, Zingiber aromaticum, and Zingiber americans). Open Access Maced. J. Med. Sci. 10(A): 695–701. Doi: 10.3889/oamjms.2022.9132.
N. A. Azelan, R. Aziz, and R. Hasham. 2018. Optimisation of Essential Oil Yield and Zerumbone Content in Zingiber zerumbet Extract using Hydrodistillation Process. Chem. Eng. Trans. 63: 595-600. Doi: 10.3303/CET1863100.
M. R. Sulaiman et al. 2010. Anti-inflammatory Effect of Zerumbone on Acute and Chronic Inflammation Models in Mice. Fitoterapia. 81(7): 855-858. Doi: 10.1016/j.fitote.2010.05.009.
A. B. H. Abdul et al. 2008. Anticancer Activity of Natural Compound (Zerumbone) Extracted from Zingiber zerumbet in Human HeLa Cervical Cancer Cells. Int. J. Pharmacol. 4(3): 160-168. Doi: 10.3923/ijp.2008.160.168.
N. M. Y. Akhtar, I. Jantan, L. Arshad, and M. A. Haque. 2019. Standardized Ethanol Extract, Essential Oil and Zerumbone of Zingiber Zerumbet Rhizome Suppress Phagocytic Activity of Human Neutrophils. BMC Complement. Altern. Med. 19(1): 331. Doi: 10.1186/s12906-019-2748-5.
M. F. R. Sam, A. Hamid, A. R. Ghazali, S. R. Louis, and S. B. Budin. 2019. Protective Effects of Zingiber Zerumbet Ethyl Acetate Extract on Hydrogen Peroxide-induced Damage of Red Blood Cells. Sains Malaysiana. 48(4): 781-790. Doi: 10.17576/jsm-2019-4804-10.
B. Dash et al. 2021. Quantitative and Chemical Fingerprint Analysis for Quality Control of Zingiber zerumbet based on HPTLC Combined with Chemometric Methods. Plant Biosyst. - An Int. J. Deal. with all Asp. Plant Biol. 155(4): 711-720. Doi: 10.1080/11263504.2020.1779840.
J. Sherma. 2010. Planar Chromatography. Anal. Chem. 82(12): 4895-4910. Doi: 10.1021/ac902643v.
V. H. Rodrigues, M. M. R. de Melo, I. Portugal, and C. M. Silva. 2018. Extraction of Eucalyptus Leaves using Solvents of Distinct Polarity. Cluster Analysis and Extracts Characterization. J. Supercrit. Fluids. 135: 263-274. Doi: 10.1016/j.supflu.2018.01.010.
S. O. Essien, B. Young, and S. Baroutian. 2020. Recent Advances in Subcritical Water and Supercritical Carbon Dioxide Extraction of Bioactive Compounds from Plant Materials. Trends Food Sci. Technol. 97(February): 156-169. Doi: 10.1016/j.tifs.2020.01.014.
I. M. A. Wahab, M. F. M. Nordin, and S. N. K. M. Amir. 2019. Subcritical Water Extraction (SWE) of Zingiber zerumbet using Two Level Full Factorial Design. Malaysian J. Fundam. Appl. Sci. 15(2): 139-145. Doi: 10.11113/mjfas.v15n2.1204.
S. N. K. M. Amir, M. F. M. Nordin, K. Shameli, zzati M. A. Wahab, and M. A. Hamid. 2020. Modeling and Optimization of Pilot-scale Subcritical Water Extraction on Zingiber zerumbet by Central Composite Design. IOP Conf. Ser. Mater. Sci. Eng. 778(1): 012077. Doi: 10.1088/1757-899X/778/1/012077.
I. M. A. Wahab et al. 2022. A Comparative Study on Zerumbone Concentration, Radical Scavenging Activity and Total Phenolic Content of Zingiber Zerumbet Extracted via Green and Conventional Extraction. Journal of Advanced Research in Applied Sciences and Engineering Technology. 1(1): 1-8.
S. N. K. M. Amir, M. F. M. Nordina, K. Shamelia, I. M. A. Wahab, and M. A. Hamid. 2021. Evaluation of Parameters For Subcritical Water Extraction of Zingiber Zerumbet Using Fractional Factorial Design .J. Teknol. 83(2): 143-150. Doi: 10.11113/jurnalteknologi.v83.14545.
N. A. Azelan, R. Hasham, M. A. Awang, R. A. Malek, N. F. Musa, and R. Aziz. 2015. Antibacterial Activity of Zingiber Officinale and Zingiber Zerumbet Essential Oils Extracted by Using Turbo Extractor Distillator (TED). J. Teknol. 77(3): 43-47. Doi: 10.11113/jt.v77.6003.
A. Ghasemzadeh, H. Z. E. Jaafar, A. Rahmat, and M. K. Swamy. 2017. Optimization of Microwave-assisted Extraction of Zerumbone from Zingiber zerumbet L. rhizome and Evaluation of Antiproliferative Activity of Optimized Extracts. Chem. Cent. J. 11(1): 1-10. Doi: 10.1186/s13065-016-0235-3.
M. N. Norfazlina et al. 2013. Cytotoxicity Study of Nigella Sativa and Zingiber zerumbet Extracts, Thymoquinone and Zerumbone Isolated on Human Myeloid Leukemia (HL60) Cell. Open Conf. Proc. J. 4(1): 99-107. Doi: 10.2174/2210289201304020099.
U. K. Ahmad, H. M. Sirat, and M. M. Sanagi. 1994. Supercritical Fluid Extraction and Capillary Gas Chromatography of the Rhizomes of Z. zerumbet. J. Microcolumn Sep. 6(1): 27-32. Doi: 10.1002/mcs.1220060107.
N. A. Nik Norulaini et al. 2009. Optimization of SC-CO2 Extraction of Zerumbone from Zingiber zerumbet (L) Smith. Food Chem. 114(2): 702-705. Doi: 10.1016/j.foodchem.2008.09.075.
J. Zhang, C. Wen, H. Zhang, Y. Duan, and H. Ma. 2020. Recent Advances in the Extraction of Bioactive Compounds with Subcritical Water: A Review. Trends Food Sci. Technol. 95(September): 183-195. Doi: 10.1016/j.tifs.2019.11.018.
A. Y. Koga, F. L. Beltrame, and A. V. Pereira. 2016. Several Aspects of Zingiber zerumbet: A Review. Rev. Bras. Farmacogn. 26(3): 385-391. Doi: 10.1016/j.bjp.2016.01.006.
S. Baby et al. 2009. High Content of Zerumbone in Volatile Oils of Zingiber zerumbet from Southern India and Malaysia. Flavour Fragr. J. 24(6): 301-308. Doi: 10.1002/ffj.1940.
K. Kalantari et al. 2017. A Review of the Biomedical Applications of Zerumbone and the Techniques for Its Extraction from Ginger Rhizomes. Molecules. 22(10): 1-24. Sep., doi: 10.3390/molecules22101645.
A. Chaudhuri, S. C. Sharma, and F. Khan. 2018. An Overview on the Advances of Zingiber zerumbet,” UK J. Pharm. Biosci. 6(5): 22. Doi: 10.20510/ukjpb/6/i5/177346.
G. C. Huang, T. Y. Chien, L. G. Chen, and C. C. Wang. 2005. Antitumor Effects of Zerumbone from Zingiber zerumbet in P-388D1 Cells In Vitro and In Vivo. Planta Med. 71(3): 219-224. Doi: 10.1055/s-2005-837820.
M. N. I. Bhuiyan, J. Uddin, Chowdhury, and J. Begum. 2008. Chemical Investigation of the Leaf and Rhizome Essential Oils of Zingiber zerumbet (L.) Smith from Bangladesh. Bangladesh J. Pharmacol. 4(1): 9-12. Doi: 10.3329/bjp.v4i1.845.
Z. A. Zakaria, A. S. Mohamad, C. T. Chear, Y. Y. Wong, D. A. Israf, and M. R. Sulaiman. 2010. Antiinflammatory and Antinociceptive Activities of Zingiber Zerumbet Methanol Extract in Experimental Model Systems. Med. Princ. Pract. 19(4): 287-294. Doi: 10.1159/000312715.
Z. A. Zakaria et al. 2011. Preliminary Analysis of the Anti-inflammatory Activity of Essential Oils of Zingiber zerumbet. Biol. Res. Nurs. 13(4): 425-432. Doi: 10.1177/1099800410386590.
Tushar, S. Basak, G. C. Sarma, and L. Rangan. 2010. Ethnomedical Uses of Zingiberaceous Plants of Northeast India. J. Ethnopharmacol. 132(1): 286-296. Doi: 10.1016/j.jep.2010.08.032.
L. N. Sutardi, I. Wientarsih, E. Handharyani, Andriani, and A. Setiyono. 2015. Indonesian Wild Ginger (Zingiber sp) Extract: Antibacterial Activity against Mycoplasma gallisepticum. IOSR J. Pharm. 5(10): 59-64. [Online]. Available: www.iosrphr.org.
M. A. Haque and I. Jantan. 2018. Recent Updates on the Phytochemistry, Pharmacological, and Toxicological Activities of Zingiber zerumbet (L.) Roscoe ex Sm. Curr. Pharm. Biotechnol. 18(9). Doi: 10.2174/1389201018666171115115458.
J. Chane-Ming, R. Vera, and J. C. Chalchat. 2003. Chemical Composition of the Essential Oil from Rhizomes, Leaves and Flowers of Zingiber Zerumbet Smith from Reunion Island. J. Essent. Oil Res. 15(3): 202-205. Doi: 10.1080/10412905.2003.9712114.
J. W. Tan, D. A. Israf, and C. L. Tham. 2018. Major Bioactive Compounds in Essential Oils Extracted From the Rhizomes of Zingiber zerumbet (L) Smith: A Mini-Review on the Anti-allergic and Immunomodulatory Properties. Front. Pharmacol. 9: 1-8. Doi: 10.3389/fphar.2018.00652.
N. S. Varier. 1943. Chemical Examination of the Rhizomes of Zingiber zerumbet, Smith. Proc. Indian Acad. Sci. - Sect. A. 20(5): 5257-5260. Doi: 10.1007/BF03046420.
S. Dev. 1960. Studies in Sesquiterpenes-XVI. Zerumbone, a Monocyclic Sesquiterpene Ketone. Tetrahedron. 8(3-4): 171-180. Doi: 10.1016/0040-4020(60)80027-0.
S. Dev. 1956. Zerumbone: A Monocyclic Sesquiterpene Ketone. Chemi. Ind. 1051.
H. S. Rahman, A. Rasedee, M. S. Chartrand, H. H. Othman, S. K. Yeap, and F. Namvar. 2014. Zerumbone Induces G2/M Cell Cycle Arrest and Apoptosis Via Mitochondrial Pathway in Jurkat Cell Line. Nat. Prod. Commun. 9(9): 1237-1242. Doi: 10.1177/1934578x1400900904.
F. Sorm. 1961. Medium-ring Terpenes. Prog. Chem. Org. Nat. Prod. 1-27.
B. R. Prema and P. K. Bhattacharyaa. 1962. Microbiological Transformations of Terpenes III. Transformations of Some Mono- and Sesqui-Terpenes. Appl. Microbiol. 10(6): 529-531. Doi: 10.1128/am.10.6.529-531.1962.
T. G. Halsall and D. W. Theobald. 1962. Recent Aspects of Sesquiterpenoid Chemistry. Q. Rev. Chem. Soc. 16(1): 101-115. Doi: 10.1039/QR9621600101.
N. P. Damodaran and S. Dev. 1965. Stereochemistry of Zerumbone. Tetrahedron Lett. 24: 1977-1981.
Parihar and Dutt. 1950. Indian Soap J. 16: 123-130.
S. Dev. 1959. Structure of Humulene. Tetrahedron Lett. 1(7): 12-15.
N. A. Sharkawi et al. 2019. Curative Potential of Zingiber zerumbet on Paracetamol-induced Hepatotoxicity. J. Malaysian Soc. Appl. Biol. 48(3): 11-17, [Online]. Available: https://www.researchgate.net/publication/334507968.
T. M. da Silva, C. D. Pinheiro, P. P. Orlandi, C. C. Pinheiro, and G. S. Pontes. 2018. Zerumbone from Zingiber zerumbet (L.) smith: A Potential Prophylactic and Therapeutic Agent against the Cariogenic Bacterium Streptococcus Mutans. BMC Complement. Altern. Med. 18(1): 1-9. Doi: 10.1186/s12906-018-2360-0.
I. Lechat-Vahirua, P. François, C. Menut, G. Lamaty, and J. M. Bessiere. 1993. Aromatic Plants of French Polynesia. I. Constituents of the Essential Oils of Rhizomes of Three Zingiberaceae: Zingiber zerumbet Smith, Hedychium coronarium Koenig and Etlingera cevuga Smith. J. Essent. Oil Res. 5(1): 55-59. Doi: 10.1080/10412905.1993.9698170.
F. Yu et al. 2008. Isolation and functional Characterization of a β-eudesmol Synthase, a New Sesquiterpene Synthase from Zingiber zerumbet Smith. FEBS Lett. 582(5): 565-572. Doi: 10.1016/j.febslet.2008.01.020.
S. Khera and S. Gupta. 2020. Zerumbone : A Magical Phytochemical. Int. J. Heal. Sci. Res. 10(October): 73-79. [Online]. Available: https://www.ijhsr.org/IJHSR_Vol.10_Issue.10_Oct2020/10.pdf.
H. S. Rahman et al. 2014. Biomedical Properties of a Natural Dietary Plant Metabolite, Zerumbone, in Cancer Therapy and Chemoprevention Trials. Biomed Res. Int. 1-20. Doi: 10.1155/2014/92074
H. M. A. Sidahmed et al. 2015. Antisecretory, Gastroprotective, Antioxidant and Anti-helicobcter Pylori Activity of Zerumbone from Zingiber Zerumbet (L.) Smith. PLoS One. 10(3): 1-21. Doi: 10.1371/journal.pone.0121060.
V. S. Rana, V. Ahluwalia, N. A. Shakil, and L. Prasad. 2017. Essential Oil Composition, Antifungal, and Seedling Growth Inhibitory Effects of Zerumbone from Zingiber zerumbet Smith. J. Essent. Oil Res. 29(4): 320-329. Doi: 10.1080/10412905.2016.1261051.
R. Hasham, N. A. Azelan, M. A. Awang, and R. Aziz. 2015. A Comparative Study on Yield of Extract, Chemical Marker Content and Antioxidant Activity of Zingiber zerumbet and Zingiber Officinale. Conf. 2nd Int. Mater. Ind. Manuf. Eng. Conf. 5: 5-9.
S. Raj, K. Harshitha, and R. A. Nair. 2022. Anti-microbial and Cytotoxic Activity of ZzAMP, a Serine Protease Inhibitor (SPI) with Nutraceutical Potential from Rhizomes of Medicinal Plant, Zingiber Zerumbet. Nat. Prod. Res. 1-6. Doi: 10.1080/14786419.2022.2032046.
M. Bandyopadhyay, A. Mukherjee, and A. Nag. 2013. Antioxidant Activities and Cytotoxicity of Zingiber zerumbet (L.) Smith Rhizome,” ~ 102 ~ J. Pharmacogn. Phytochem. 2(3): 102-108.
H. Ali, R. Y. Hasi, M. Islam, S. Haque, and M. F. Alkhanani. 2022. Antioxidant, Cytotoxic and Apoptotic Activities of the Rhizome of Zingiber Zerumbet Linn. in Ehrlich ascites Carcinoma Bearing Swiss Albino Mice. Sci. Rep. 1-11. Doi: 10.1038/s41598-022-15498-8.
A. P. Raina and R. C. Misra. 2022. Zingiber zerumbet (L.) Roscoe ex Smith: A Potential Source of Zerumbone Rich Essential Oil. Med. Plants. 14(1): 162-168. Doi: 10.5958/0975-6892.2022.00018.1.
R. C. Padalia et al. 2018. Zingiber Zerumbet (L.) Roscoe ex Sm. from Northern India: Potential Source of Zerumbone Rich Essential Oil for Antiproliferative and Antibacterial Applications. Ind. Crops Prod. 112(January): 749-754. Doi: 10.1016/j.indcrop.2018.01.006.
C. B. Singh, S. B. Chanu, L. Kh, N. Swapana, C. Cantrell, and S. A. Ross. 2014. Chemical Composition and Biological Activity of the Essential Oil of Rhizome of Zingiber zerumbet (L.) Smith. J. Pharmacogn. Phytochem. 3(3): 130-133.
M. Ungsurungsie and O. Suthienkul. 1982. Mutagenicity Screening of Popular Thai Spices. Food Chem. Toxicol. 20(5): 527-530. Doi: 10.1016/S0278-6915(82)80059-8.
L. T. Huong et al. 2020. Zingiber zerumbet Rhizome Essential Oil: Chemical Composition, Antimicrobial and Mosquito Larvicidal Activities. European J. Med. Plants. 30(4): 1-12. Doi: 10.9734/ejmp/2019/v30i430197.
G. Kader, F. Nikkon, M. A. Rashid, and T. Yeasmin. 2011. Antimicrobial Activities of the Rhizome Extract of Zingiber zerumbet Linn. Asian Pac. J. Trop. Biomed. 1(5): 409-412. Doi: 10.1016/S2221-1691(11)60090-7.
N. Aji, S. Kumala, E. Mumpuni, and D. Rahmat. 2022. Antibacterial Activity and Active Fraction of Zingiber officinale Roscoe, Zingiber montanum (J.Koenig) Link ex A., and Zingiber zerumbet (L.) Roscoe ex Sm. Against Propionibacterium Acnes. Pharmacogn. J. 14(1): 103-111. Doi: 10.5530/pj.2022.14.15.
T. M. Jien, S. N. Parvin Ab Hamid, N. F. Md Hashim, N. Armania, H. I. Saidi, and N. M. Zakuan. 2020. Zerumbone Induces Cytotoxicity and Inhibits Cell Migration of Human Colon Cancer Cells. Sains Malaysiana. 49(6): 1359-1370. Doi: 10.17576/jsm-2020-4906-14.
T. Sithara et al. 2018. Zerumbone, a Cyclic Sesquiterpene from Zingiber zerumbet Induces Apoptosis, Cell Cycle Arrest, and Antimigratory Effects in SW480 Colorectal Cancer Cells. J. Agric. Food Chem. 66(3): 602-612. Doi: 10.1021/acs.jafc.7b04472.
S. I. Abdelwahab et al. 2011. Zerumbone Induces Apoptosis in T-acute Lymphoblastic Leukemia Cells. Leuk. Res. 35(2): 268-271. Doi: 10.1016/j.leukres.2010.07.025.
R. abd R. Pihie and A. H. Lope. 2005. The Antiproliferative Effects of Zingiber zerumbet Extracts and Fractions on the Growth of Human Breast Carcinoma Cell Lines,” Malaysian J. Pharm. Sci. 3(1): 45-52. [Online]. Available: http://web.usm.my/mjps/mjps03012005/mjps03012005_5.pdf.
H. S. Rahman et al. 2013. Zerumbone-loaded Nanostructured Lipid Carriers: Preparation, Characterization, and Antileukemic Effect. Int. J. Nanomedicine. 8: 2769-2781. Doi: 10.2147/IJN.S45313.
S. I. Abdelwahab et al. 2010. Regression of Cervical Intraepithelial Neoplasia by Zerumbone in Female Balb/c Mice Prenatally Exposed to Diethylstilboestrol: Involvement of Mitochondria-regulated Apoptosis. Exp. Toxicol. Pathol. 62(5): 461-469. Doi: 10.1016/j.etp.2009.06.005.
A. Hamid et al. 2018. Cytotoxicity Evaluation of Zingiber Zerumbet Ethyl Acetate Extract on K-562, Erythroleukemia Cell Line. Pharmacogn. Mag. 14(57): 5430-5433. Doi: 10.4103/pm.pm_436_17.
U. Sriphana, S. Pitchuanchom, P. Kongsaeree, and C. Yenjai. 2013. Antimalarial Activity and Cytotoxicity of Zerumbone Derivatives. ScienceAsia. 39(1): 95-99. Doi: 10.2306/scienceasia1513-1874.2013.39.095.
Y. Wu et al. 2017. Contact and Repellant Activities of Zerumbone and Its Analogues from the Essential Oil of Zingiber zerumbet (L.) Smith against Lasioderma serricorne. J. Oleo Sci. 66(4): 399-405, Doi: 10.5650/jos.ess16166.
S. I. Abdelwahab, A. B. Abdul, A. S. Alzubairi, M. Mohamed Elhassan, and S. Mohan. 2009. In Vitro Ultramorphological Assessment of Apoptosis Induced by Zerumbone on (HeLa). J. Biomed. Biotechnol. 1-10. Doi: 10.1155/2009/769568.
S. I. Abdelwahab, A. B. Abdul, H. C. Yeel, A. S. Alzubain, M. M. Elhassan, and M. M. Syam. 2008. Anti-tumor Activities of Analogues Derived from the Bioactive Compound of Zingiber Zerumbet. Int. J. Cancer Res. 4(4): 154-159. Doi: 10.3923/ijcr.2008.154.159.
A. Murakami, M. Takahashi, S. Jiwajinda, K. Koshimizu, and H. Ohigashi. 1999. Identification of Zerumbone in Zingiber zerumbet Smith as a Potent Inhibitor of 12- O -Tetradecanoylphorbol-13-acetate-induced Epstein-Barr Virus Activation. Biosci. Biotechnol. Biochem. 63(10): 1811-1812. Doi: 10.1271/bbb.63.1811.
S. F. A. Albaayit, M. A. Khan, and R. Abdullah. 2021. Zerumbone Induces Growth Inhibition of Burkitt’s Lymphoma Cell Line Via Apoptosis. Nat. Volatiles Essent. Oils. 8(3): 56-63. Doi: 10.37929/nveo.927770.
M. M. E. Taha, A. B. Abdul, R. Abdullah, T. A. T. Ibrahim, S. I. Abdelwahab, and S. Mohan. 2010. Potential Chemoprevention of Diethylnitrosamine-initiated and 2-acetylaminofluorene-promoted Hepatocarcinogenesis by Zerumbone from the Rhizomes of the Subtropical Ginger (Zingiber zerumbet). Chem. Biol. Interact. 186(3): 295-305. Doi: 10.1016/j.cbi.2010.04.029.
J.-R. Dai, J. H. C. II, J. B. M. Mahon, and M. R. Boyd. 1997. Zerumbone, an HIV-Inhibitory and Cytotoxic Sesquiterpene of Zingiber Aromaticum and Z. Zerumbet. Nat. Prod. Lett. 10(2): 115-118. Doi: 10.1080/10575639208048891.
L. Yan, Y. Cao, and G. Zheng. 2017. Optimization of Subcritical Water Extraction of Phenolic Antioxidants from Pomegranate (: Punica granatum L.) Peel by Response Surface Methodology. Anal. Methods. 9(32): 4647-4656. Doi: 10.1039/c7ay01475a.
M. A. Haque, I. Jantan, H. Harikrishnan, and S. 2019. Standardized Extract of Zingiber zerumbet suppresses LPS-induced pro-inflammatory responses through NF-κB, MAPK and PI3K-Akt signaling pathways in U937 macrophages. 54. Elsevier GmbH.
T. Y. Chien, L. G. Chen, C. J. Lee, F. Y. Lee, and C. C. Wang. 2008. Anti-inflammatory Constituents of Zingiber zerumbet. Food Chem. 110(3): 584-589. Doi: 10.1016/j.foodchem.2008.02.038.
Y.-H. Shieh, H.-M. Huang, C.-C. Wang, C.-C. Lee, C.-K. Fan, and Y.-L. Lee. 2015. Zerumbone Enhances the Th1 Response and Ameliorates Ovalbumin-induced Th2 Responses and Airway Inflammation in Mice. Int. Immunopharmacol. 24(2): 383-391. Doi: 10.1016/j.intimp.2014.12.027.
S. Tewtrakul and S. Subhadhirasakul. 2007. Anti-allergic Activity of Some Selected Plants in the Zingiberaceae Family. J. Ethnopharmacol. 109(3): 535-538. Doi: 10.1016/j.jep.2006.08.010.
J. N. Foong et al. 2018. Zerumbone-Loaded Nanostructured Lipid Carrier Induces Apoptosis of Canine Mammary Adenocarcinoma Cells. Biomed Res. Int. 1-18. Doi: 10.1155/2018/8691569.
B. Dash et al. 2022. Zingiber zerumbet Rhizome Essential Oil Induces Cytotoxicity, Apoptosis and Cell Cycle Arrest in Jurkat Cells. J. Essent. Oil-Bearing Plants. 25(3): 639-650. Doi: 10.1080/0972060X.2022.2098062.
M. R. Sulaiman et al. 2009. Preliminary Analysis of the Antinociceptive Activity of zerumbone. Fitoterapia. 80(4): 230-232. Doi: 10.1016/j.fitote.2009.02.002.
M. H. Khalid et al. 2011. Antinociceptive Effect of the Essential Oil of Zingiber zerumbet in Mice: Possible Mechanisms. J. Ethnopharmacol. 137(1): 345-351. Doi: 10.1016/j.jep.2011.05.043.
S. Matsumura, K. Murata, Y. Yoshioka, and H. Matsuda. 2016. Search for β-Secretase Inhibitors from Natural Spices. Nat. Prod. Commun. 11(4): 507-510. Doi: 10.1177/1934578x1601100423.
K. Murata, Y. Ishida, A. Nishio, S. Nakagawa, H. Kawamoto, and H. Matsuda. 2017. Screening of Spice Extracts Possessing Anti-acetylcholinesterase Activity and Active Principle of Bitter Ginger, Rhizome of Zingiber Zerumbet. Nat. Prod. Commun. 12(7): 1053-1056. Doi: 10.1177/1934578x1701200713.
T.-F. Tzeng, S.-S. Liou, Y.-C. Tzeng, and I.-M. Liu. 2016. Zerumbone, a Phytochemical of Subtropical Ginger, Protects against Hyperglycemia-Induced Retinal Damage in Experimental Diabetic Rats. Nutrients. 8(8): 1-14. Doi: 10.3390/nu8080449.
T.-Y. Hong, T.-F. Tzeng, S.-S. Liou, and I.-M. Liu. 2016. The Ethanol Extract of Zingiber zerumbet Rhizomes Mitigates Vascular Lesions in the Diabetic Retina. Vascul. Pharmacol. 76: 18-27. Doi: 10.1016/j.vph.2015.08.015.
C. J. Chang, S.-S. Liou, T.-F. Tzeng, and I.-M. Liu. 2014. The Ethanol Extract of Zingiber Zerumbet Smith Attenuates Non-alcoholic Fatty Liver Disease in Hamsters Fed on High-Fat Diet. Food Chem. Toxicol. 65(20101018): 33-42. Doi: 10.1016/j.fct.2013.11.048.
M. N. Somchit, M. H. N. Shukriyah, A. A. Bustamam, and A. Zuraini. 2005. Anti-pyretic and Analgesic Activity of Zingiber zerumbet. Int. J. Pharmacol. 1(3): 277-280. Doi: 10.3923/ijp.2005.277.280.
M. Jyothilakshmi, M. Jyothis, G. Narayanan, and M. Latha. 2017. Antidermatophytic and Protease-inhibiting Activities of Zerumbone: A Natural Sesquiterpene from the Rhizome of Zingiber zerumbet (L.) Roscoe ex J.E; Smith. Pharmacogn. Mag. 13(49): 2-6. Doi: 10.4103/0973-1296.197649.
S. F. A. Albaayit. 2021. Enzyme Inhibitory Properties of Zerumbone. Pakistan J. Agric. Sci. 58(3): 1207-1209. Doi: 10.21162/PAKJAS/21.9759.
N. E. Mohamad et al. 2015. Nanostructured Lipid Carrier Improved in Vivo Anti-tumor and immunomodulatory Effect of Zerumbone in 4T1 Challenged Mice. RSC Adv. 5(28): 22066-22074. Doi: 10.1039/c5ra00144g.
N. S. Ghazalee, I. Jantan, L. Arshad, and M. A. Haque, . 2019. Immunosuppressive Effects of the Standardized Extract of Zingiber zerumbet on Innate Immune Responses in Wistar Rats. Phyther. Res. 33(4): 929-938. Doi: 10.1002/ptr.6285.
Y. S. Keong, N. B. Alitheen, S. Mustafa, S. A. Aziz, M. A. Rahman, and A. M. Ali. 2010. Immunomodulatory Effects of Zerumbone Isolated from Roots of Zingiber zerumbet. Pak. J. Pharm. Sci. 23(1): 75-82.
C. J. Chang, T. F. Tzeng, S. S. Liou, Y. S. Chang, and I. M. Liu. 2012. Absence of Genotoxic and Mutagenic Effects of Zingiber zerumbet (L.) Smith (Zingiberaceae) Extract. Evidence-based Complement. Altern. Med. Doi: 10.1155/2012/406296.
I. Jantan, M. A. Haque, M. Ilangkovan, and L. Arshad. 2019. Zerumbone from Zingiber Zerumbet Inhibits Innate and Adaptive Immune Responses in Balb/C mice. Int. Immunopharmacol. 73(June): 552-559. Doi: 10.1016/j.intimp.2019.05.035.
N. Saravanabavan, K. J. Salwe, R. Sudar Codi, and M. Kumarappan. 2020. Herbal Extraction Procedures: Need of the Hour. Int. J. Basic Clin. Pharmacol. 9(7): 1135. Doi: 10.18203/2319-2003.ijbcp20202566.
Q. W. Zhang, L. G. Lin, and W. C. Ye. 2018. Techniques for Extraction and Isolation of Natural Products: A Comprehensive Review. Chinese Med. (United Kingdom). 13(1): 1-26.Doi: 10.1186/s13020-018-0177-x.
N. Bousbia, M. Abert Vian, M. A. Ferhat, E. Petitcolas, B. Y. Meklati, and F. Chemat. 2009. Comparison of Two Isolation Methods for Essential Oil from Rosemary Leaves: Hydrodistillation and Microwave Hydrodiffusion and Gravity. Food Chem. 114(1): 355-362. Doi: 10.1016/j.foodchem.2008.09.106.
Downloads
Published
Issue
Section
License
Copyright of articles that appear in Jurnal Teknologi belongs exclusively to Penerbit Universiti Teknologi Malaysia (Penerbit UTM Press). This copyright covers the rights to reproduce the article, including reprints, electronic reproductions, or any other reproductions of similar nature.
