Development of Spectral Delayed Luminescence System for Whole Saliva Analysis: A Prototype Study

Authors

  • Mohd Najeb Jamaludin Faculty Biosciences and Medical Engineering, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia
  • Malarvili Balakrishnan Faculty Biosciences and Medical Engineering, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia

DOI:

https://doi.org/10.11113/jt.v67.1969

Keywords:

Delayed luminescence, spectral, prototype, whole saliva

Abstract

This paperwork presents the development of spectral delayed luminescence system for the measurement of whole saliva. Despite various reports of delayed luminescence and its correlation to various diseases, it has fail to highlight the specific cause of the occurrence suggesting it being more suitable as a screening tool utilizing saliva as non-invasive sampling medium. Therefore it is the aim of this paper to have the system critical performance tested before putting it to use at the field. The system prototype is tested for its response during room temperature operation and during spot cooling of the photomultiplier tube module. Delayed luminescence of saliva is compared over distilled water as a control. The spectral delayed luminescence of saliva is compared to that of the dimmed white light for functional testing purposes. Through experiments, the best operation for the system is at constant room temperature with light stimulation time determined at 150 ms. Being 98% water, the delayed luminescence of saliva is slightly greater than that of distilled water. Given light stimulation of wide spectrum from white LED, the delayed luminescence of saliva is accumulated between 495 nm and 530 nm. Results demonstrated that the system for spectral delayed luminescence of saliva is viable and capable for acquiring data for further studies.

 

Author Biographies

  • Mohd Najeb Jamaludin, Faculty Biosciences and Medical Engineering, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia
    Tutor at Faculty Biosciences and Medical Engineering
  • Malarvili Balakrishnan, Faculty Biosciences and Medical Engineering, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia
    Senior Lecturer, Faculty Biosciences and Medical Engineering

References

Abiko, Y., Saitoh, M. 2007. Curr Pharm Des. 13: 3065–72.

Pink, R., Simek, J., Vondrakova, J., Faber, E., Michl, P., et al. 2009. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 153: 103–10.

Saroch, G., Paul, M. P. R. 2012. Egyptian Journal of Forensic Sciences. 2: 123–125.

Tan, X., Song, Z. 2013. Applied Spectroscopy. 67: 54–8.

Li, X., Yang, T., Lin, J. 2012. Journal of Biomedical Optics. 17: 0370031–5.

Hans, K. M. C., Müller, S., Sigrist, M. W. 2012. Drug Testing and Analysis. 4: 420–9.

Goncharov, N., Katsya, G., Dobracheva, A., Nizhnik, A., Kolesnikova, G., et al. 2006. The Aging Male. 9: 111–22.

Popp, F. A., Yan, Y. 2002. Physics Letters A. 293: 93–7.

Scordino, A., Triglia, A., Musumeci, F., Grasso, F., Rajfur, Z. 1996. Journal of Photochemistry and Photobiology B: Biology. 32: 11–7.

Bajpai, R. P. 1999. J Theor Biol. 198: 287–99.

Slawinski, J., Ezzahir, A., Godlewski, M., Kwiecinska, T., Rajfur, Z., et al. 1992. Experientia. 48: 1041–58.

Chen, P., Zhang, L., Mao, S-C, Li, X., Zhang, F., et al. 2013. J. Opt. Technol. 80: 115–8.

Kim, H-W, Sim, S-B, Kim, C-K, Kim, J, Choi, C., et al. 2005. Cancer Letters 229: 283–9.

Musumeci, F., Scordino, A., Tudisco, S., Applegate, L. A., Niggli, H. J. 2005. Spectral Analysis of Delayed Luminescence as a Tool to Discriminate between Normal and Cancer Skin Cells.

Niggli, H. J., Tudisco, S., Lanzano, L., Applegate, L. A., Scordino, A., Musumeci, F. 2008. Indian J Exp Biol. 46: 358–63.

Lanzanò, L., Scordino, A., Privitera, S., Tudisco, S., Musumeci, F. 2007. European Biophysics Journal. 36: 823–9.

Van, Wijk EPA, Van, Wijk R., Bosman, S. 2010. Journal of Photochemistry and Photobiology B: Biology. 98: 199–206.

Musumeci, F., Applegate, L. A., Privitera, G., Scordino, A., Tudisco, S., Niggli, H. J. 2005. Journal of Photochemistry and Photobiology B: Biology. 79: 93–9.

Kim, H., Ahn, S., Kim, J., Soh, K-S. 2008. Ultrasonics Sonochemistry. 15: 921–6.

Van, Wijk R., Wiegant, F. A. C., Popp, F. A., Storms, GEMG. 1994. Biophoton Emission from Blood Serum of Diabetic Patients. Lille, France.

Chen, P., Zhang, L., Zhang, F., Liu, J-T, Bai, H., et al. 2012. Biomed. Opt. Express. 3: 1787–92.

Inaba, H. 1988. Cellular and Molecular Life Sciences. 44: 550–9.

Kobayashi, M., Inaba, H. 2001. E-1: 214–20.

Scordino, A., et al. 2008. Journal of Physics D: Applied Physics. 41: 155507

Kim, H., Ahn, S., Kim, J. 2007. 1277–80.

Baran, I., Ganea, C., Privitera, S., Scordino, A., Barresi, V., et al. 2012. Oxidative Medicine and Cellular Longevity. 2012: 14.

Bai, H,, Lin, L,, Chen P, Tang G. 2007. 68260Q–Q.

Najeb, J. M., Arief, R., SH-Hussain, S. 2005. Proceedings of the International Conference on Robotics, Vision, Information and Signal Processing: 83–6.

Bai, H., Chen, P., Lin, L., Chang, S., Tang, G., Mu, G. 2009. 71820K–K.

Rollie, M. E., Patonay, G., Warner, I. M. 1987. Analytical Chemistry. 59: 180–4.

Vesetova, T. V., Veselovsky, V. A., Rubin, A. B., Bochvarov, P. Z. 1985. Physiologia Plantarum. 65: 493–7.

Downloads

Published

2014-02-26

Issue

Section

Science and Engineering

How to Cite

Development of Spectral Delayed Luminescence System for Whole Saliva Analysis: A Prototype Study. (2014). Jurnal Teknologi, 67(1). https://doi.org/10.11113/jt.v67.1969