Design of Low Power Integrated CMOS Potentiometric Biosensor for Direct Electronic Detection of DNA Hybridization
DOI:
https://doi.org/10.11113/jt.v67.2054Keywords:
Potentiometric, CMFET, DNA, CMOS, low-powerAbstract
The purpose of this research is to design a low power integrated complementary metal oxide semiconductor (CMOS) detection circuit for charge-modulated field-effect transistor (CMFET) and it is used for the detection of deoxyribonucleic acid (DNA) hybridization. With the available CMOS technology, it allows the realization of complete systems which integrate the sensing units and transducing elements in the same device. Point-of-care (POC) testing device is a device that allows anyone to operate anywhere and obtain immediate results. One of the important features of POC device is low power consumption because it is normally battery-operated. The power consumption of the proposed integrated CMOS detection circuit requires only 14.87 mW. The detection circuit will amplify the electrical signal that comes from the CMFET to a specified level in order to improve the recording characteristics of the biosensor. Self-cascode topology was used in the drain follower circuit in order to reduce the channel length modulation effect. The proposed detection circuit was designed with 0.18µm Silterra CMOS fabrication process and simulated under Cadence Simulation Tool.
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References
P. bergveld. 2003. Thirty Year of ISFETOLOGY: What Happened in the Past 30 Years and What May Happen in the Next 30 Years. J. Sensors and Actuators B. 88: 1–20.
K. H. Lee et. al. 2011. A DNA Potentiometric FET Sensor Based on the Direct Charge Accumulation. 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences. 604–606.
B. Chen et al. 2008. Biochemical Sensing of Charged Polyelectrolytes with a Novel CMOS Floating-gate Device Architecture. IEEE International Conference on Electro Information Technology. 300.
S. Shao et al. 2009. An Ultrasensitive Field-effect Charge Sensor For Label-free Biomolecules Detection. Conference on Lasers & Electro Optics & The Pacific Rim Conference on Lasers and Electro-Optics. 1: 1–2.
S. Lai et al. 2012. A CMOS Biocompatible Charge Detector for Biosensing Applications. J. IEEE Transactions on Electron Devices. 59: 2512–2519.
M. D. Ventra et al. 2004. DNA electronics. Encyclopedia of nanoscience and nanotechnology. 10: 1-19.
M. Barbaro et al. 2006. A charge-modulated FET for Detection of Biomolecular Processes: Conception, Modeling And Simulation. J. IEEE Transactions on Electron Devices. 53: 158–166.
D. J. Lockhart et al. 1996. Expression Monitoring by Hybridization to High-density Oligonucleotide Arrays. J. Nature Biotechnology. 14: 1675–1680.
F. Bertucci et al. 1999. Sensitivity Issues in DNA Array-based Expression Measurements and Performance of Nylon Microarrays for Small Samples. J. Hum. Mol. Genet. 8: 1715–1722.
H. Salin et al. 2002. A Novel Sensitive Microarray Approach for Differential Screening Using Probes Labeled with Two Different Radioelements. J. Nucl. Acid Res. 30: 4.
M. Ohura et al. 2006. An Analog BioCMOS LSI Circuit for the Electrical Detection of Biomolecular Charges with Extended Gate MOSFET Cells. IEEJ International Analog VLSI Workshop. 1–6.
W. Y. Chung et al. 2006. New ISFET Interface Circuit Design with Temperature Compensation. J. Microelectronics. 37: 1105–1114.
K. Nakazato. 2009. An Integrated ISFET Sensor Array. J. Sensors. 9: 8831–8851.
I. Eldbib et al. 2008. Self-cascode Current Controlled CCII Based-Tunable Band Pass Filter. Radioelektronika 18th International Conference. 1–4.
C. Galup et al. 1994. Series-parallel Association Of FET’s for High Gain and High Frequency Applications. J. IEEE. 29: 1094–1101.
Z. Liu et al. 2005. Full Custom Design of a Two-stage Fully Differential CMOS Amplifier with High Unity-gain Bandwidth and Large Dynamic Range at Output. 48th IEEE International Midwest Symposium on Circuits and Systems.2: 984–987.
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