EFFECTS OF BLAINVILLEA ACMELLA ON THE BONE MECHANICAL PROPERTIES OF OVARIECTOMIZED RATS

Authors

  • Mohd Maaruf Abdul Malik Faculty of Dentistry, Universiti Teknologi MARA, Sungai Buloh Campus, Jalan Hospital, 47000 Sungai Buloh, Selangor Darul Ehsan, Malaysia ᵇFaculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, Jalan Hospital, 47000 Sungai Buloh, Selangor Darul Ehsan, Malaysia https://orcid.org/0000-0002-5676-3715
  • Goot Heah Khor Faculty of Dentistry, Universiti Teknologi MARA, Sungai Buloh Campus, Jalan Hospital, 47000 Sungai Buloh, Selangor Darul Ehsan, Malaysia
  • ‘Atiqah Azam Faculty of Dentistry, Universiti Teknologi MARA, Sungai Buloh Campus, Jalan Hospital, 47000 Sungai Buloh, Selangor Darul Ehsan, Malaysia
  • Nurul Raudzah Adib Ridzuan Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, Jalan Hospital, 47000 Sungai Buloh, Selangor Darul Ehsan, Malaysia
  • Elvy Suhana Mohd Ramli Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, 56000 Cheras, Kuala Lumpur, Malaysia
  • Isa Naina Mohamed Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, 56000 Cheras, Kuala Lumpur, Malaysia
  • Ahmad Nazrun Shuid Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, Jalan Hospital, 47000 Sungai Buloh, Selangor Darul Ehsan, Malaysia

DOI:

https://doi.org/10.11113/jurnalteknologi.v87.23320

Keywords:

Bone mechanical properties, Blainvillea acmella, osteoporosis, ovariectomised rat, three-point bending

Abstract

A metabolic bone disorder known as osteoporosis is represented by low mineral bone mass and strength. Blainvillea acmella (BA), a herbal plant with antioxidant properties have exhibited anti-osteoporosis effects. The present study set out to discover the osteoprotective effects of BA on bone mechanical properties of the ovariectomized rat model of osteoporosis. Twenty-four Sprague-Dawley female rats were designated into four groups (n=6 per group), namely, (SHAM) sham-operated, (OVX) ovariectomized control, (OVX+E) ovariectomized and supplemented with Premarin 64.5 µg/kg and (OVX+BA) ovariectomized and supplemented with 100 mg/kg of BA ethanolic leaves extract. All rats were euthanized after 12 weeks and the right femurs were tested in three-point bending using Instron Universal Test Machine (Shimadzu AG-X 500N). The bone mechanical properties were evaluated in two parts: extrinsic factors (load, displacement and stiffness) as well as intrinsic factors (stress, strain and Young modulus). The maximum stress and Young modulus of OVX+E and OVX+BA groups indicated considerably higher levels compared to SHAM and OVX groups (p<0.05). No significant differences were found in bone strength between OVX+E and OVX+BA groups. In conclusion, BA leaves extract was comparable to Premarin in maintaining optimal bone strength of the ovariectomized rat model of osteoporosis. Therefore, BA potential in treatment of osteoporosis warrants further investigation.

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Published

2025-08-22

Issue

Vol. 87 No. 5: September 2025

Section

Science and Engineering

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How to Cite

EFFECTS OF BLAINVILLEA ACMELLA ON THE BONE MECHANICAL PROPERTIES OF OVARIECTOMIZED RATS. (2025). Jurnal Teknologi (Sciences & Engineering), 87(5), 967-974. https://doi.org/10.11113/jurnalteknologi.v87.23320