PEMAJUAN BIOLOGI SINTETIK MIKROB DALAM MEMACU KERANGKA BIOLOGI KEJURUTERAAN (EngBio) DAN BIOEKONOMI KITARAN DI MALAYSIA

ADVANCING MICROBIAL SYNTHETIC BIOLOGY TO DRIVE ENGINEERING BIOLOGY (EngBio) AND CIRCULAR BIOECONOMY DEVELOPMENT IN MALAYSIA

Authors

  • Matthlessa Matthew Minggu ᵃInstitut Biologi Sistem (INBIOSIS), Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia ᵇNatural Resources and Environment Board Sarawak, 18th-20th Floor, Menara Pelita, Jalan Tun Abdul Rahman Yaakub, Petra Jaya, 93050 Kuching, Locked Bag 2103, Sarawak, Malaysia
  • Nur Anisza Hanoum Naseron ᵃInstitut Biologi Sistem (INBIOSIS), Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia ᶜPoliteknik Nilai, Kompleks Pendidikan Nilai, Bandar Enstek, 71760 Labu, Negeri Sembilan, Malaysia
  • Peer Mohamed Abdul ᵈJabatan Kejuruteraan Kimia dan Proses, Fakulti Kejuruteraan dan Alam Bina, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia ᵉPusat Penyelidikan Teknologi Proses Mampan (CESPRO), Fakulti Kejuruteraan dan Alam Bina, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia
  • Zool Hilmi Ibrahim Petronas Research Sdn Bhd (PRSB), Lot 3288 & 3289, Off Jalan Ayer Itam, Kawasan Institusi Bangi, 43000, Kajang, Selangor, Malaysia
  • Kumar Sudesh ᵍEcobiomaterial Research Laboratory, School of Biological Sciences, Universiti Sains Malaysia, Gelugor, Penang, 11800, Malaysia ʰDepartment of Microbiology, Faculty of Science, Chulalongkorn University, Phayathai Road, Patumwan, Bangkok 10330, Thailand
  • Ahmad Bazli Ramzi Institut Biologi Sistem (INBIOSIS), Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia

DOI:

https://doi.org/10.11113/jurnalteknologi.v88.24616

Keywords:

Microbial synthetic biology, Engineering Biology, biomanufacturing, biosynthesis of monomers and polymers, biofuels, low-carbon bioproducts, circular bioeconomy

Abstract

Environmental sustainability is very important to ensure the country’s sustainable economic development in the long term. Advances in synthetic biology and microbial engineering have grown rapidly to meet the global need to develop sustainable and effective biological-based products (bioproducts) via Engineering Biology (EngBio) framework. Bioproduction and biorefining methods, which use renewable raw materials such as plant biomass and industrial waste to produce biological products, can be used as modular platforms to produce low carbon bioproducts. Guided by the cyclical bioeconomic model, this review study focuses on using synthetic biology and microbial engineering in the research and production of bioproducts, especially for studies involving local research groups. Emphasis is placed on the development of microorganisms as chassis and genetic building blocks that can be used in biotransformation and biomanufacturing, such as the production of monomers, polymers, and bio-based fuels. The important role of synthetic biology and microbial engineering in helping the development of sustainable bioproducts and circular bioeconomy in Malaysia was also discussed to provide a framework for synthetic biology and EngBio in Malaysia, in line with the Malaysian Biotechnology Policy 2.0 (2022–2030).

 

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2026-06-16

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Vol. 88 No. 4: July 2026

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Science and Engineering

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