INHIBITORY EFFECT OF ARTOCARPUS LOWII KING COMPOUNDS ON COX-2 AND 15-LO ACTIVITIES
DOI:
https://doi.org/10.11113/jt.v76.3652Keywords:
Artocarpus lowii King, Anti-inflammatory, Cyclooxygenase-2, IsobavachalconeAbstract
Artocarpus lowii King is a rare species of plant in Moraceae family. In this study, the anti-inflammatory activity of cycloheterophyllin, isobavachalcone, 4-hydroxylonchocarpin and 2’,4’-dihydroxy-4-methoxy-3’-prenyldihydroxychalcone isolated from A. lowii King were investigated on classical enzymes in arachidonic acid metabolism pathways; cyclooxygenase and lipoxygenase. Isobavachalcone directly inhibited cyclooxygenase-2 enzyme in dose dependent manner, with IC50 value of 0.95 μM. No noticeable effect has been observed with the other tested compounds. In addition, none of the tested compounds displays a direct inhibition on 15-lipoxygenase when compared to the resveratrol as control with the IC50 value of 1.5 μM. Isobavachalcone showed inhibitory effect on cyclooxygenase-2. This study suggests that A. lowii King contains potential anti-inflammatory activity.
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