DETECTION OF DIFFERENT CONCENTRATIONS OF URIC ACID USING TAPERED SILICA OPTICAL SENSOR COATED WITH ZINC OXIDE (ZNO)
DOI:
https://doi.org/10.11113/jt.v74.4724Keywords:
Optical fiber, uric acid, zinc oxide (ZnO)Abstract
The working principle of measurement of output power from silica optical sensor for the detection of different concentrations of uric acid is demonstrated. The fabricated sensors used single mode silica optical fibers (SOF) which were tapered using flame brushing technique to achieve a waist diameter of 32 µm and tapering length of 2 mm. The tapered fiber were then coated with ZnO nanostructures using sol–gel immersion method. The concentration of the uric acid is measured in volume parts per million (ppm) for a concentration change from 0 ppm to 500 ppm by tapered SOF coated with ZnO and non-coated sensors. The peak voltage increases linearly for coated and non-coated from 214 mV to 268 mV and 270 mv to 344 mV, respectively. Sensitivity was measured with 0.11 mV/ppm and 0.15 mV/ppm, respectively. In addition, the results show that the linearity of the sensors is 94.56% and 97.78%, respectively. Simple in fabrication and low in cost, this sensor can detect concentration changes of uric acid in a fast and convenient way with high stability and sensitivity. Thus, this sensor will be very promising in chemical and biomedical applications.
References
So, A., & Thorens, B. 2010. Uric Acid Transport and Disease. The Journal of Clinical Investigation. 120(6): 1791-1799.
Fang, J. I., Wu, J. S., Yang, Y. C., Wang, R. H., Lu, F. H., & Chang, C. J. High Uric Acid Level Associated with Increased Arterial Stiffness in Apparently Healthy Women. Atherosclerosis. 236(2): 389-393.
Du, T., Sun, X., Lu, H., Lin, X., Liu, Q., Huo, R., & Yu, X. 2014. Associations of Serum Uric Acid Levels with Cardiovascular Health Factors: Differences by Sex, Age and Body Mass Index in Chinese Participants. European Journal of Internal Medicine. 25(4): 388-393.
Viazzi, F., Garneri, D., Leoncini, G., Gonnella, A., Muiesan, M. L., Ambrosioni, E., & Pontremoli, R. 2014. Serum Uric Acid and Its Relationship with Metabolic Syndrome and Cardiovascular Risk Profile in Patients with Hypertension: Insights from the I-DEMAND Study. Nutrition, Metabolism and Cardiovascular Diseases.
Ivekovic, D., Japec, M., Solar, M., & Živkovic, N., Amperometric Uric Acid Biosensor with Improved Analytical Performances Based on Alkaline-Stable H2O2 Transducer. Int. J. Electrochem. Sci. 7: 3252-3264.
Shen, W. J., Zhuo, Y., Chai, Y. Q., Han, J., & Yuan, R. 2014. An Enzyme-free Signal Amplified Strategy Based on Hollow Platinum Nanochains Catalyzed Oxidation of Uric Acid for Electrochemical Aptasensor Construction. Electrochimica Acta. 143: 240-246.
Oukil, D., Benhaddad, L., Aitout, R., Makhloufi, L., Pillier, F., & Saidani. 2014. B., Electrochemical Synthesis of Polypyrrole Films Doped by Ferrocyanide Ions onto Iron Substrate: Application in the Electroanalytical Determination of Uric Acid. Sensors and Actuators B: Chemical. 204: 203-210.
Tang, C. F., Kumar, S. A., & Chen, S. M. 2008. Zinc Oxide/redox Mediator Composite Films-based Sensor for Electrochemical Detection of Important Biomolecules. Analytical Biochemistry. 380(2): 174-183.
Anusha, J. R., Kim, H. J., Fleming, A. T., Das, S. J., Yu, K. H., Kim, B. C., & Raj, C. J. 2014. Simple Fabrication of ZnO/Pt/chitosan Electrode for Enzymatic Glucose Biosensor. Sensors and Actuators B: Chemical. 202: 827-833.
Tian, Y., Wang, W., Wu, N., Zou, X., & Wang, X. 2011. Tapered Optical Fiber Sensor for Label-free Detection of Biomolecules. Sensors. 11(4): 3780-3790.
Batumalay, M., Harith, Z., Rafaie, H. A., Ahmad, F., Khasanah, M., Harun, S. W., & Ahmad, H. 2014. Tapered Plastic Optical Fiber Coated with Zno Nanostructures for the Measurement of Uric Acid Concentrations and Changes in Relative Humidity. Sensors and Actuators A: Physical. 210: 190-196.
Downloads
Published
Issue
Section
License
Copyright of articles that appear in Jurnal Teknologi belongs exclusively to Penerbit Universiti Teknologi Malaysia (Penerbit UTM Press). This copyright covers the rights to reproduce the article, including reprints, electronic reproductions, or any other reproductions of similar nature.
