ANTIOXIDANT AND ANTI-CANCER ACTVITY OF STANDARDIZED EXTRACTS OF THREE VARIETIES OF Ficus deltoidea’s LEAVES

Authors

  • Husnul Hanani Soib Department of Bioprocess Engineering, Faculty of Chemical Engineering, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia
  • Ismail Ware Department of Bioprocess Engineering, Faculty of Chemical Engineering, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia
  • Harisun Yaakob Department of Bioprocess Engineering, Faculty of Chemical Engineering, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia
  • Hanafi Mukrish Department of Bioprocess Engineering, Faculty of Chemical Engineering, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia
  • Mohamad Roji Sarmidi Department of Bioprocess Engineering, Faculty of Chemical Engineering, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia

DOI:

https://doi.org/10.11113/jt.v77.6000

Keywords:

F. deltoidea, antioxidant, anti-cancer

Abstract

The present study was designed to evaluate the antioxidant and anti-cancer activities of aqueous extracts of three varieties of Ficus deltoidea (var. angustifolia, var. deltoidea, var. kunstleri) on prostate cancer DU145 cell line. The results showed that, F. deltoidea var. kunstleri contained the highest total phenolic (44.7 ± 0.022 mg GAE/10 g sample) and flavonoid contents (23.1 ± 0.005 mg CE/10 g sample) as well as the highest radical scavenging activity (IC50 0.039 mg/mL) followed by F. deltoidea var. deltoidea and F. deltoidea var. angustifolia. Similarly, based on anti-cancer activities, F. deltoidea var. kunstleri demonstrated the lowest IC50 value (93.11 mg/mL) followed by F. deltoidea var. deltoidea (204.17 mg/mL) and F. deltoidea var. angustifolia (429.54 mg/mL). Other than that, vitexin which is a bioactive marker was appeared to be the highest in F. deltoidea var. kunstleri compared to others. Hence, the results suggested that there might be an association between antioxidant activities and bioactive markers against prostate cancer cell line (DU145).

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Published

2015-10-28

How to Cite

ANTIOXIDANT AND ANTI-CANCER ACTVITY OF STANDARDIZED EXTRACTS OF THREE VARIETIES OF Ficus deltoidea’s LEAVES. (2015). Jurnal Teknologi, 77(3). https://doi.org/10.11113/jt.v77.6000