Prediction of Protein Secondary Structure

Abstract

Dengan wujudnya projek jujukan DNA secara besar–besaran, teknik yang tepat untuk meramalkan struktur protein diperlukan. Masalah meramalkan struktur protein daripada jujukan DNA pada dasarnya masih belum dapat diselesaikan walaupun kajian intensif telah dilakukan selama lebih daripada tiga dekad. Dalam kertas kerja ini, teori asas struktur protein akan dibincangkan sebagai panduan umum bagi kajian peramalan struktur protein sekunder. Analisis jujukan terkini serta prinsip yang digunakan dalam teknik–teknik tersebut akan diterangkan. Kata kunci: Peramalan struktur sekunder protein; Rangkaian Neural In the wake of large-scale DNA sequencing projects, accurate tools are needed to predict protein structures. The problem of predicting protein structure from DNA sequence remains fundamentally unsolved even after more than three decades of intensive research. In this paper, fundamental theory of the protein structure will be presented as a general guide to protein secondary structure prediction research. An overview of the state–of–the–art in sequence analysis and some principles of the methods involved wil be described. Key words: Protein secondary structure prediction; Neural networks