DOSAGE AND ADMINISTRATION LENGTH OF CENTELLA ASIATICA (L.) URBAN DECREASE THE LEVEL OF SOD AND MDA AND IMPROVE BRAIN HISTOLOGICAL CONDITION OF RATS

Authors

  • Bayyinatul Muchtaromah Department of Biology, Faculty of Science and Technology, State Islamic University of Malang, Indonesia
  • Mujahidin Ahmad Department of Biology, Faculty of Science and Technology, State Islamic University of Malang, Indonesia
  • Suyono Suyono Department of Biology, Faculty of Science and Technology, State Islamic University of Malang, Indonesia
  • Romaidi Romaidi Department of Biology, Faculty of Science and Technology, State Islamic University of Malang, Indonesia
  • Samsul Bahri Department of Biology, Faculty of Science and Technology, State Islamic University of Malang, Indonesia
  • Hasnia Prinha Kumalasari Department of Biology, Faculty of Science and Technology, State Islamic University of Malang, Indonesia

DOI:

https://doi.org/10.11113/jt.v78.8238

Keywords:

Daylight factor ß, window to wall ratio (WWR), window to floor ratio (WFR)

Abstract

Medicinal plants have been used for treating many kinds of illness due to their safety, cheap and easy to be accessed by all level of society. This study was aimed to determine the effect of the dosage forms (fresh, boiled and ethanol extracted) and the duration (24 and 42 days) of medicinal plant Centella asiatica to the levels of superoxide dismutase (SOD), malondialdehyde (MDA) and the histopathology of diabetic rat brain. The results showed that administration of various dosage forms of C. asiatica were able to increase the number of pyramid cells and neuroglia in the cerebrum significantly (P <0.01) but had no significant effect (P>0.01) at the administration length and the interaction between both treatments. This finding resulted in the new traditional herbal medicine that can be used for treating degenerative disorders on nervous system.

References

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Published

2016-04-18

Issue

Vol. 78 No. 5: May 2016

Section

Science and Engineering

License

Copyright of articles that appear in Jurnal Teknologi belongs exclusively to Penerbit Universiti Teknologi Malaysia (Penerbit UTM Press). This copyright covers the rights to reproduce the article, including reprints, electronic reproductions, or any other reproductions of similar nature.

How to Cite

DOSAGE AND ADMINISTRATION LENGTH OF CENTELLA ASIATICA (L.) URBAN DECREASE THE LEVEL OF SOD AND MDA AND IMPROVE BRAIN HISTOLOGICAL CONDITION OF RATS. (2016). Jurnal Teknologi, 78(5). https://doi.org/10.11113/jt.v78.8238