INVESTIGATION OF NEW NSAIDS FOR THE TREATMENT OF INFLAMMATORY DISEASES OF KIDNEY AND URINARY TRACT
DOI:
https://doi.org/10.11113/jt.v78.8643Keywords:
Pain, analgesic, phenolic glycosides, writhing testAbstract
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used in the world, primarily due to their high efficiency for the treatment of inflammatory induced pain syndrome. The main feature of NSAIDs is a combination of anti-inflammatory, analgesic, antipyretic, and anticoagulant properties. However, their long-term use is associated with side effects in the gastrointestinal tract including peptic ulcers and other. We developed and synthesized molecule of methyl (4-О-β-glucopyranosyloxy)-benzoic acid. The anti-inflammatory effect of methyl (4-О-β-glucopyranosyloxy)-benzoic acid evaluated using the carrageenan-induced hindpaw edema model. The study shows that the intragastrically administration of test substance to animals reduces inflammatory process.
References
Pirmohamed, M., James, S., Meakin, S. et al. 2004. Adverse Drug Reactions Ascause Of Admission To Hospital: Prospective Analysis Of 18 820 Patients. BMJ. 329: 15.
Rayburn, E. R., Ezell, S. J., & Zhang, R. 2009. Anti-Inflammatory Agents For Cancer Therapy. Molecular And Cellular Pharmacology. 1(1): 29-43.
Ridker, P. M., & Lüscher, T. F. 2014. Anti-Inflammatory Therapies For Cardiovascular Disease. European Heart Journal. 35(27): 1782-1791.
Lanas, A. 2009. Nonsteridal Antiinflammatory Drugs And Cyclooxygenase Inhibition In The Gastrointestinal Tract: A Trip From Peptic Ulcer To Colon Cancer. The American Journal Of The Medical Sciences. 15: 96-106.
Fortun, P. J., Hawkey. C. J. 2007 Non-Steroidal Anti-Inflammatory Drugs And The Small Intestine. Current Opinion In Gastroenterology. 23(2): 134-41.
Bjorkman, D. J. 1999. Current Status Of Nonsteroidal Anti-Inflammatory Drugs (NSAID) Use In The United States: Risk Factors And Frequency Of Complications. Am J Med. 107: 3S-8S
IAAAS. 1986. Risk Of Agranulocytosis And Aplastic Anemia. JAMA. 256: 1749-1757.
Strom, B. L., Carson, J. L., Schinnarr, et al. 1993. Nonsteroidal Anti-Inflammatory Drugs And Neutropenia. Arch Intern Med. 153: 2119.
Bort, R., Ponsoda, X., Jover, R. et al. 1999. Diclofenac Toxicity To Hepatocytes: A Role For Drug Metabolism In Cell Toxicity. J Pharmacol Exp Ther. 288(1): 65-72.
Yeon Soo Lee. 2001. Practical Î’-Stereoselective O-Glycosylation Of Phenols With Penta-O-Acetyl-Î’-D-Glucopyranose, Journal Of Carbohydrate Chemistry. 20(6): 503-506.
Stepanova, E. V., Belyanin, M. L., Filimonov, V. D. 2014. Synthesis Of Acyl Derivatives Of Salicin, Salirepin And Arbutin Carbohydr. Res. 388: 105-111.
Mendes, S. S., Bomfim, R. R., Jesus, H.C.R., Alves, P. B., Blank, A. F., Estevam, C. S., An Toniolli, A. R., Thomazzi, S. M. 2010. Evaluation Of The Analgesic And Anti-Inflammatory Effects Of The Essential Oil Of Lippia Gracilis Leaves. J. Ethno-Pharmacol. 129: 391-397.
Winter, C. A., Risley, E. A., Nuss, G. W. 1962. Carrageenin-Induced Edema In Hind Paw Of The Rat As An Assay For Anti-Inflammatory Drugs. Proc. Soc. Exp. Biol. Med. 111: 544-547.
El-Shenawy, S. M., Abdel-Salam, O. M. E., Baiuomy, A. R., El-Batran, S., Arbid, M. S. 2002. Studies On The Anti-Inflammatory And Antinociceptive Effects Of Melatonin In The Rat. Pharmacol Res. 46: 235-243.
Brooks, P. M. 1991. Day RO: Non-Steroidal Anti-Inflammatory Drugs - Differences And Similarities. New Eng J Med. 324: 1716-1725.
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