EXPLORING THE DICHOTOMY OF TRANSCRANIAL MAGNETIC STIMULATION’S FREQUENCIES ON BRAIN WAVE PATTERNS
DOI:
https://doi.org/10.11113/jt.v78.9049Keywords:
Brain stimulation, cortical plasticity, electroencephalography (EEG), neuromodulation, neural oscillationsAbstract
Disturbance in brain oscillations is observed in many neuropsychiatric disorders. Any tool that has the potential to restore abnormal brain oscillations is therefore beneficial to patients with neuropsychiatric illnesses. Repetitive transcranial magnetic stimulation (rTMS) is one such tool. It is a non-invasive brain stimulation technique, which is able to alter brain oscillations depending on its parameters of stimulation and is used in clinical setting because of its potential therapeutic effects on the brain. However, the optimum stimulation parameters to induce the therapeutic effect of rTMS remains elusive. Therefore, it is important to investigate the differential effects between high versus low frequency of magnetic stimulation on the mechanism of brain oscillations in human subjects. Here we show, using combined rTMS and surface electroencephalography (EEG) that low and high frequencies of magnetic stimulation would induce dichotomy effects in EEG brain oscillatory activity. In particular, high-frequency rTMS 10Hz induces a synchronised oscillations for theta brain rhythm. In contrast, low-frequency rTMS 1Hz desynchronises neural oscillations on the same brain rhythm. Taken together, our results show that the desynchronisation effect of low-frequency rTMS 1Hz may potentially reverse the interference of altered neural oscillations. More extensive basic and clinical research using combined rTMS and EEG are needed to determine the optimum parameters of rTMS stimulation to restore adequate neural oscillations.
References
Hallett, M. 2000. Transcranial Magnetic Stimulation and the Human Brain. Nature. 406: 147-150.
Hoogendam, J. M. Ramakers, G. M. and Di Lazzaro, V. 2010. Physiology of Repetitive Transcranial Magnetic Stimulation of the Human Brain. Brain Stimulation 3: 95-118.
Miniussi, C. and Thut, G. 2010. Combining TMS and EEG Offers New Prospects in Cognitive Neuroscience. Brain Topography. 22: 249-256.
Frohlich, F. 2015. Experiments and Models of Cortical Oscillations as a Target for Noninvasive Brain Stimulation. Progress in Brain Research. doi:10.1016/bs.pbr.2015.07.025.
Brignani, D. Manganotti, P. Rossini, P. M. and Miniussi, C. 2008. Modulation of Cortical Oscillatory Activity during Transcranial Magnetic Stimulation. Hum Brain Mapp. 29: 603-612.
Fuggetta, G. Pavone, E. F. Fiaschi, A. and Manganotti, P. 2008. Acute Modulation of Cortical Oscillatory Activities during Short Trains of High-Frequency Repetitive Transcranial Magnetic Stimulation of the Human Motor Cortex: a Combined EEG and TMS study. Hum Brain Mapp. 29: 1-13.
Veniero, D. Brignani, D. Thut, G. and Miniussi, C. 2011. Alpha-generation as Basic Response-Signature to Transcranial Magnetic Stimulation (TMS) Targeting the Human Resting Motor cortex: A TMS/EEG Co-Registration Study. Psychophysiology. 48: 1381-1389.
Pfurtscheller, G. and Lopes da Silva, F. H. 1999. Event-Related EEG/MEG Synchronization and Desynchronization: Basic Principles. Clin Neurophysiol. 110: 1842-1857.
Llinas, R. R. Ribary, U. Jeanmonod, D. Kronberg, E. and Mitra, P. P. 1999. Thalamocortical Dysrhythmia: A Neurological and Neuropsychiatric Syndrome Characterized by Magnetoencephalography. Proceedings of the National Academy of Sciences of the United States of America. 96: 15222-15227.
Jeanmonod, D. 2003. Neuropsychiatric Thalamocortical Dysrhythmia: Surgical Implications. Neurosurg Clin N Am. 14: 251-265.
Whitwell, J. L. 2011. Disrupted Thalamocortical Connectivity in PSP: A Resting-state fMRI, DTI, and VBM Study. Parkinsonism & Related Disorders. 17: 599-605.
Llinas, R. R. and Steriade, M. 2006. Bursting of Thalamic Neurons and States of Vigilance. Journal Of Neurophysiology. 95: 3297-3308.
Thut, G. and Pascual-Leone, A. 2010. A Review of Combined TMS-EEG Studies to Characterize Lasting Effects of Repetitive TMS and Assess Their Usefulness in Cognitive and Clinical Neuroscience. Brain Topography. 22: 219-232.
Noh, N.A. and Fuggetta, G. 2012. Human Cortical Theta Reactivity After Repetitive Transcranial Magnetic Stimulation. Hum Brain Mapp. 33: 2224-2237.
Fuggetta, G. and Noh, N.A. 2013. A Neurophysiological Insights Into the Potential Link Between Transcranial Magnetic Stimulation, Thalamocortical Dysrhythmia and Neuropsychiatric Disorders. Experimental Neurology. 245: 87-95.
Noh, N.A. Fuggetta, G. Manganotti, P. and Fiaschi, A. 2012. Long Lasting Modulation of Cortical Oscillations after Continuous Theta Burst Transcranial Magnetic Stimulation. PloS One. 7(4): e35080.
Allen, E. A. Pasley, B. N. Duong, T. and Freeman, R. D. 2007. Transcranial Magnetic Stimulation Elicits Coupled Neural and Hemodynamic Consequences. Science. 317: 1918-1921.
Buzsaki, G. and Draguhn, A. 2004. Neuronal Oscillations in Cortical Networks. Science. 304: 1926-1929.
Ridder, D. Vanneste, S. Langguth, B. and Llinas, R. 2015. Thalamocortical Dysrhythmia: a Theoretical Update in Tinnitus. Frontiers in Neurology. doi: 10.3389/fneur.2015.00124.
Chervyakov, A. V. Chernyavsky, A. Y. Sinitsyn, D. O. and Piradov, M. A. 2015. Possible Mechanisms Underlying the Therapeutic Effects of Transcranial Magnetic Stimulation. Frontiers in Human Neurosc. doi: 10.3389/fnhum.2015.00303.
Gosseries, O. Thibaut, A. Boly, M. Rosanova, M. Massimini, M. Laureys, S. 2014. Assessing Consciousness in Coma and Related States Using Transcranial Magnetic Stimulation. Ann Fr Anesth Reanim. 33: 65-71
Kerdvibulvech, C. 2014. A Methodology for Hand and Finger Motion Analysis Using Adaptive Probabilistic Models. EURASIP Journal on Embedded Systems. 18.
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