BONY TRABECULAR MICRO-STRUCTURE AND POROSITY WITH AGE IN YOUNG RABBIT’S FEMUR: IN-VIVO STUDY
DOI:
https://doi.org/10.11113/jt.v78.9056Keywords:
Micro-CT, bone morphology, bony trabecular structure, total porosityAbstract
The established of micro computed tomography (micro-CT) analysis software make it compatible to use to determine abnormality of bone morphology. This study investigated 90 new rabbits for bony trabecular microstructure and porosity after their dams were exposed to ultrasound at the second stage of pregnancy (duration - 90 minutes; frequency - 7.09 MHz; spatial peak temporal average intensity (SPTA) - 49.4 W/cm2; power - 56 W; thermal index (TI) - 0.2; mechanical index (MI) - 1.0). A femur of five groups of litters (n = 18 litters per group): 1, 2, 3, 4 and 5 month-old was excised and scanned using SkyscanTM 1176. For total porosity, a significant difference was shown in at two month-old group (p = 0.017). A significant difference was also shown in bony trabecular thickness for three month-old group (p < 0.05). For trabecular separation, there was a significant difference at four month-old group (p = 0.040). This study suggested that there might be some significant differences in bony trabecular structure and total porosity with ages. This may be due to heat created by ultrasound exposure, which can apply effect to bone morphology. To determine whether the findings are applicable to human, clinical trials should be carried out in the future.
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