• Ruhaizan Ismail Department of Control and Mechatronics Engineering, Faculty of Electrical Engineering, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia
  • Herlina Abdul Rahim Department of Control and Mechatronics Engineering, Faculty of Electrical Engineering, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia
  • Intan Maisarah Abd Rahim Department of Control and Mechatronics Engineering, Faculty of Electrical Engineering, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia
  • Rashidah Ghazali Department of Control and Mechatronics Engineering, Faculty of Electrical Engineering, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia



Near Infrared Spectroscopy (NIRS), biomarker, blood parameter, leukemia screening, non-invasive, invasive


Near Infrared Spectroscopy (NIRS) has been applied as analytical tool in numerous field of study due to its ability in non-invasive application. NIRS with the ability in providing the information on biological molecules shows a high potential as a diagnosis tool in medical as diseased related to biochemistry changes of the cell and tissue. This paper reviewed the application of NIR spectroscopy in leukemia screening and in other medical application. General comparison between invasive and non-invasive NIR spectroscopy method is provided. The author also proposed a new non-invasive NIRS method in leukemia screening and compared it with the previous invasive NIRS method.


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