The Effect of Virgin Coconut Oil Loaded Solid Lipid Particles (VCO-SLPs) on Skin Hydration and Skin Elasticity
DOI:
https://doi.org/10.11113/jt.v62.1248Keywords:
solid lipid particles, virgin coconut oil, ultrasonification, moisturizerAbstract
Virgin Coconut Oil is oil extracted from well matured and fresh coconut through specialized processes without damaging its natural nutrition. In this work virgin coconut oil is loaded into solid lipid microparticles to be used in a moisturizer formulation. The virgin coconut oil loaded solid lipid microparticles were prepared using ultrasonification of molten stearic acid and virgin coconut oil in an aqueous solution and microparticles with the size of 0.608 µm have been obtained. 20% concentration of VCO-SLPs of 0.608 µm particle size was added into the base lotion. Sensory study and skin evaluation study was conducted to compare the difference between lotion containing VCO-SLPs and lotion without VCO-SLPs. Moisturizer incorporated with 20% VCO-SLPs was found to be the best effective as a moisturizer compared to the placebo lotion.
References
Ramalho A, Silva CL, Pais AACC, Sousa, JJS. In vivo friction study of human skin: Influence of moisturizers on different anatomical sites. Wear 2007; 263(7-12), 1044-1049.
Brummer R. Rheology Essentials of Cosmetic and Food Emulsions. 1st ed. Unnastr, Hamburg: Springer Berlin Heidelberg New York; 2006.
Wickett RR & Visscher MO. Structure and function of the epidermal barrier. Am J Infect Control 2006; 34(10, Suppl 1): S98-S110.
Godin B & Touitou E. Transdermal skin delivery: Predictions for humans from in vivo, ex vivo and animal models. Adv. Drug Deliv. Rev 2007; 59(11), 1152-1161.
Elsner P, Maibach HI. Eds. Cosmeceuticals: Drugs vs. Cosmetic (Cosmetic Science and Technology Series / Volume 23, New York : Marcel Dekker Inc. 2000.
Flynn TC, Petros J, Clark RE, Viehman GE. Dry Skin and Moisturizers. Clin Dermatol 2001; 19: 387-392.
Marina AM, Man YBC, Nazimah SAH, Amin I. Chemical Properties of Virgin Coconut Oil. J Am Oil Chem Soc. 2009; 86: 301-307.
Müller RH, Radtke M, Wissing SA. Solid Lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations. Adv Drug Deliv Rev. 2002; (54, Suppl 1): S131-S155.
Mulla, J. S. and Khazi, I. M. (2009). Short Communication : Influence of process variables on particle size of solid lipid nanoparticles. Indian Journal of Novel Drug Delivery 1(1); 47-49
Zhang, D., Tan, T. and Gao, L. (2006). Preparation of oridonin-loaded solid lipid nanoparticles and studies on them in vitro and in vivo. Nanotechnology 17; 5821–5828
Jones, L.V., Peryman, D.R. and Thurstone, L.L. (1955). Development of a Scale for Measuring Soldiers Food Preferences. Food Res. 20: 512-520.
Barbaud A. (2005). Drug Patch Testing in Systemic Cutaneous Drug Allergy. Toxicol. 209; 209-16
Verma, D. D., Verma, S., Blume, G. and Fahr, A. (2003). Particle Size of Liposomes Influences Dermal Delivery of Substances into Skin. International Journal of Pharmaceutics 258; 141–151.
Aramwit, P., Kanokpanont, S., Nakpheng, T. and Srichana, T. (2010). The Effect of Sericin from Various Extraction Methods on Cell Viability and Collagen Production. Int. J. Mol. Sci. 11; 2200-2211
American Society for Testing and Materials (1985). Zeta Potential of Colloids in Water and Waste Water ASTM Standard D 4187-82. West Conshohocken, PA, USA.
Freitas, C. and Müller, R. H. (1998). Effect of Light and Temperature on Zeta Potential and Physical Stability in Solid Lipid Nanoparticles (SLN) Dispersions. Int J Phar.,168; 221
Souto, E. B., Muller, R. H. and Alemieda, A. J. (2007). Topical delivery of oily actives using solid lipid particles. Pharmaceutical Technology Europe. 19(12)
Wissing, S.A, and Muller R.H. (2002). The Influence of the Crystallinity of Lipid Nanoparticles on their Occlusive Properties. Int J Pharm. 242; 377-379.
Hommoss, A. (2008). Nanostructured Lipid Carriers (NLC) in Dermal and Personal Care Formulations. Free University Berlin. Ph. D Dissertation.
Müller, R.H., Hommoss A., Pardeike, J., and Schmidt, C. (2007). Lipid nanoparticles (NLC) as novel carrier for cosmetics - Special features & state of commercialisation, SÖFW; (9): 40-46
Pardeike, J., Hommoss, A., Müller, R.H. (2009). Lipid nanoparticles (SLN, NLC) in Cosmetic and Pharmaceutical Dermal Products. International Journal of Pharmaceutics. 366; 170-184.
Flynn, T. C., Petros, J., Clark, R. E., Viehman, G. E. (2001). Dry Skin and Moisturizers. Clinics in Dermatology. 19, 387-392.
Baran, R. and Maibach, H. (1998). Textbook of Cosmetic Dermatology. (2nd edition). Singapore: Kyodo Printing Co (S’pore) Pte Ltd.
Wissing, S. A. and Müller, R. H. (2003a). Cosmetic Applications for Solid Lipid Nanoparticles (SLN). International Journal of Pharmaceutics. 254; 65-68.
Wissing, S. A. and Müller, R. H. (2003b). The influence of solid lipid nanoparticles on skin hydration and viscoelasticity--in vivo study. Eur J Pharm Biopharm; 56 (1); 67-72
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