GOOD CORRELATION BETWEEN TWO DIFFERENT AUTOMATED FACTOR XIII ASSAYS AND PRACTICAL RECOMMENDATIONS

Authors

  • Suryati Hussin Haematology Department, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kelantan, Malaysia
  • Zamzuri Idris Neurosurgery Department, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kelantan, Malaysia
  • Wan Zaidah Abdullah Haematology Department, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kelantan, Malaysia

DOI:

https://doi.org/10.11113/jt.v79.10840

Keywords:

Factor XIII activity, factor XIII antigen assay, haemostasis, neurosurgery and automated coagulation analyzer

Abstract

Coagulation factor XIII (FXIII) can be quantitatively measured by using modern automated coagulation analyzers. It was uncertained whether different methods of FXIII quantitative measurement are correlated. Two different analytical methods were used for comparison in this study. This study selected a neurosurgical patient population for FXIII measurement, expecting a wide spectrum of results from haemostatic changes in vivo. A correlation study between FXIII activity (Berichrom F XIII, Dade Behring Marburg GmbH) and FXIII antigen assay (HemosILâ„¢, Instrumentation Laboratory Company, Milano Italy) was performed using two different automated coagulation analyzers and test principles. FXIII assays using these two methods were performed on blood specimen from 84 patients taken pre and post neurosurgical procedures. A total of one hundred and thirty eight blood samples were included in this correlation study. There was a significant mean different of FXIII antigen levels pre and post intracranial surgery (p< 0.05). A significant, positive and good correlation between FXIII antigen and activity assays were documented by both methods, r = 0.86, and p<0.001. FXIII antigens are correlated with FXIII activity assays indicating the reliability and robustness of both methods for quantitation of FXIII in the blood. These two methods are recommended for both diagnostic and research purposes.

Author Biographies

  • Suryati Hussin, Haematology Department, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kelantan, Malaysia
    Haematology Department
  • Zamzuri Idris, Neurosurgery Department, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kelantan, Malaysia
    Neurosciences Department
  • Wan Zaidah Abdullah, Haematology Department, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kelantan, Malaysia
    Haematology Department

References

Kohler, H. P., Ichinose, A., Seitz, R., Ariens, R. A. and Muszbek, L. 2011. Diagnosis and Classification of Factor XIII Deficiencies. J Thromb Haemost. 9(7): 1404-1406. doi: 10.1111/j.1538-7836.2011.04315.x.

Gerlach, R., Tölle, F., Raabe, A., Zimmermann, M., Siegemund, A. and Seifert, V. 2002. Increased Risk for Postoperative Haemorrhage After Intracranial Surgery in Patients with Decreased Factor XIII Activity: Implications of a Prospective Study. Stroke. 33: 1618-23.

Teich, M., Longin, E., Dempfle, C. E. and König, S. 2004. Factor XIII Deficiency Associated with Valproate Treatment. Epilepsia. 45(2): 187-89.

Inbal, A., Oldenburg, J., Carcao, M., Rosholm, A., Tehranchi, R. and Nugent, D. 2012. Recombinant Factor XIII: A Safe and Novel Treatment for Congenital Factor XIII Deficiency. Blood. 119(22): 5111-5117.

Naderi, M., Dorgalaleh, A., Tabibian, S., Alizadeh, S., Eshghi, P. and Solaimani, G. 2013. Current Understanding in Diagnosis and Management of Factor XIII Deficiency. Iranian Journal of Pediatric Hematology and Oncology. 3(4): 164.

Martinuzzo, M., Barrera, L., Altuna, D., Baña, F. T., Bieti, J., Amigo, Q., D’Adamo, M., López, M., Oyhamburu, J. and Otaso, J. 2016. Effects of Factor xiii Deficiency on Thromboelastography. Thromboelastography with Calcium and Streptokinase Addition is More Sensitive than Solubility Tests. Mediterranean Journal of Hematology and Infectious Diseases. 8(1).

Muszbek, L., Adány, R. and Mikkola, H. 1996. Novel Aspects of Blood Coagulation Factor XIII. I. Structure, Distribution, Activation, and Function. Crit Rev Clin Lab Sci. 33(5): 357-421.

Shi, D. Y., and Wang, S. J. 2017. Advances of Coagulation Factor XIII. Chin Med J (Engl). 130(2): 219-223. doi: 10.4103/0366-6999.198007.

Tahlan, A. and Ahluwalia, J. 2014. Factor XIII: Congenital Deficiency Factor XIII, Acquired Deficiency, Factor XIII A-subunit, and Factor XIII B-subunit. Arch Pathol Lab Med. 138(2): 278-81. doi: 10.5858/arpa.2012-0639-RS.

Peyvandi, F., Palla, R., Menegatti, M., Siboni, S. M., Halimeh, S., Faeser, B., Pergantou, H., Platokouki, H., Giangrande, P., Peerlinck, K., Celkan, T., Ozdemir, N., Bidlingmaier, C., Ingerslev, J., Giansily-Blaizot, M., Schved, J. F., Gilmore, R., Gadisseur, A., Benedik-Dolnicar, M., Kitanovski, L., Mikovic, D., Musallam, K. M. and Rosendaal, F. R. 2012. Coagulation Factor Activity and Clinical Bleeding Severity in Rare Bleeding Disorders: Results from the European Network of Rare Bleeding Disorders. [Multicenter Study Research Support, Non-U.S. Gov't]. J Thromb Haemost. 10(4): 615-621. doi: 10.1111/j.1538-7836.2012.04653.x.

Ivaskevicius, V., Biswas, A., Bevans, C., Schroeder, V., Kohler, H. P., Rott, H.and Oldenburg, J. 2010. Identification of Eight Novel Coagulation Factor XIII Subunit a Mutations: Implied Consequences for Structure and Function. Haematologica. 95(6): 956-962. doi: 10.3324/haematol.2009.017210.

Thomas, A., Biswas, A., Ivaskevicius, V. and Oldenburg, J. 2015. Structural and Functional Influences of Coagulation Factor XIII Subunit B Heterozygous Missense Mutants. Mol Genet Genomic Med. 3(4): 258-271. doi: 10.1002/mgg3.138.

Dorgalaleh, A., Naderi, M., Hosseini, M. S., Alizadeh, S., Hosseini, S., Tabibian, S. and Eshghi, P. 2015. Factor XIII Deficiency in Iran: A Comprehensive Review of the Literature. Paper Presented at the Seminars in Thrombosis and Hemostasis.

Biswas, A., Ivaskevicius, V., Thomas, A. and Oldenburg, J. 2014. Coagulation factor XIII deficiency. Diagnosis, prevalence and Management of Inherited and Acquired Forms. Hamostaseologie. 34(2): 160-166. doi: 10.5482/HAMO-13-08-0046.

Schroeder, V. and Kohler, H. P. 2013. Factor XIII Deficiency: an Update. Paper Presented at the Seminars in Thrombosis and Hemostasis. 39(6): 632-41. doi: 10.1055/s-0033-1353392.

Muszbek, L., Bagoly, Z., Cairo, A. and Peyvandi, F. 2011. Novel Aspects of Factor XIII Deficiency. Current Opinion in Hematology. 18(5): 366-372.

Dorgalaleh, A., Tabibian, S., Shams, M., Tavasoli, B., Gheidishahran, M. and Shamsizadeh, M. 2016. Laboratory Diagnosis of Factor XIII Deficiency in Developing Countries: An Iranian Experience. Lab Med. 47(3): 220-226. doi: 10.1093/labmed/lmw021.

Hsu, P., Zantek, N. D., Meijer, P., Hayward, C. P., Brody, J., Zhang, X. and Van Cott, E. M. 2014. Factor XIII Assays and Associated Problems for Laboratory Diagnosis of Factor XIII Deficiency: An Analysis of International Proficiency Testing Results. Semin Thromb Hemost. 40(2): 232-238. doi: 10.1055/s-0034-1365841.

Sanfelippo, M. J., Mazza, J. J. and Mercier, R. J. 2014. Symptomatic Factor XIII Deficiency with Normal Urea Solubility Test. Clin Lab. 60(12): 2099-2102.

Lawrie, A., Green, L., Mackie, I., Liesner, R., Machin, S. and Peyvandi, F. 2010. Factor XIII–an Under Diagnosed Deficiency–are We Using The Right Assays? Journal of Thrombosis and Haemostasis. 8(11): 2478-2482.

Dorgalaleh, A., Tabibian, S., Hosseini, M. S., Farshi, Y., Roshanzamir, F., Naderi, M. and Shamsizadeh, M. 2016. Diagnosis of Factor XIII Deficiency. Hematology. 21(7): 430-439.

Noll, T., Wozniak, G., Mohammad, A. and Piper, H. M. 1999. Effect of Factor XIII on Endothelial Barrier Function. J Exp Med. 189(9): 1373-82.

Idris, Z., Muzaimi, M., Hussin, S., Mahmood, W. H. and Abdullah, W. Z. 2012. Association of Perioperative Factor XIII Activity Levels and Other Haemostatic Markers with the Risk of Postoperative Intracranial Haematoma in a Selected Cohort Of Neurosurgical Patients. Acta Neurochir. 154(5): 887-894.

Bosche, B., Molcanyi, M., Noll, T., Kochanek, M., Kraus, B., Rieger, B., El Majdoub, F., Dohmen, C., Lohr, M., Goldbrunner, R. and Brinker, G. 2013. Occurrence and Recurrence of Spontaneous Chronic Subdural Haematoma Is Associated with A Factor XIII Deficiency. Clin Neurol Neurosurg. 115(1): 13-8.

Gödje, O., Gallmeier, U., Schelian, M., Grünewald, M. and Mair, H. 2006. Coagulation Factor XIII Reduces Postoperative Bleeding After Coronary Surgery with Extracorporeal Circulation. Thorac Cardiovasc Surg. 54(1): 26-33.

Alhomsi, K., Salem, R. O., Morin, K. A. and Van Cott, E. M. 2007. Evaluation of a New, Automated Quantitative Factor XIII Assay. XXIst Congress of the International Society on Thrombosis and Haemostasis. Geneva, Switzerland. July 6-12.

Cini, M., Legnani, C., Frascaro, M., Pancani, C., Cappelli, C., Rodorigo, G., Valdrè, L, and Cosmi, B. 2016. Measurement of Factor XIII (FXIII) Activity by an Automatic Ammonia Release Assay Using Iodoacetamide Blank-Procedure: No More Overestimation In The Low Activity Range And Better Detection of Severe FXIII Deficiencies. Clin Chem Lab Med. 54(5): 805-9.

Jennings, I., Kitchen, S., Woods, T. and Preston, F. 2003. Problems Relating to the Laboratory Diagnosis of Factor XIII Deficiency: A UK NEQAS study. Journal of Thrombosis and Haemostasis. 1(12): 2603-2608.

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Published

2017-10-22

Issue

Vol. 79 No. 7: November 2017

Section

Science and Engineering

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Copyright of articles that appear in Jurnal Teknologi belongs exclusively to Penerbit Universiti Teknologi Malaysia (Penerbit UTM Press). This copyright covers the rights to reproduce the article, including reprints, electronic reproductions, or any other reproductions of similar nature.

How to Cite

GOOD CORRELATION BETWEEN TWO DIFFERENT AUTOMATED FACTOR XIII ASSAYS AND PRACTICAL RECOMMENDATIONS. (2017). Jurnal Teknologi, 79(7). https://doi.org/10.11113/jt.v79.10840