GELLAN GUM- AND PECTIN-MAGNETIC GRAPHENE OXIDE NANOCARRIERS LOADED WITH CINNAMALDEHYDE FOR MOSQUITO LARVAE CONTROL

Siew Tin Susana Wong; Azlan Kamari; Siti Najiah Mohd Yusoff; Mohd Zobir Hussein; Hidayatulfathi Othman; Suzaliza Mustafar; Adulsman Sukkaew; Is Fatimah

doi:10.11113/jurnalteknologi.v86.20213

Authors

Siew Tin Susana Wong Department of Chemistry, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, 35900 Tanjong Malim, Perak, Malaysia https://orcid.org/0009-0009-3349-3132
Azlan Kamari Department of Chemistry, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, 35900 Tanjong Malim, Perak, Malaysia https://orcid.org/0000-0002-3167-0619
Siti Najiah Mohd Yusoff Department of Chemistry, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, 35900 Tanjong Malim, Perak, Malaysia https://orcid.org/0000-0002-7343-0461
Mohd Zobir Hussein Institute of Nanoscience and Nanotechnology, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia
Hidayatulfathi Othman School of Diagnostic and Applied Health Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, 50300 Kuala Lumpur, Malaysia https://orcid.org/0000-0002-1430-3438
Suzaliza Mustafar Department of Chemistry, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, 35900 Tanjong Malim, Perak, Malaysia https://orcid.org/0000-0002-0658-5076
Adulsman Sukkaew Faculty of Science Technology and Agriculture, Yala Rajabhat University, 133 Thesaban 3, Sateng, Muang, Yala, 95000, Thailand https://orcid.org/0000-0002-5087-0157
Is Fatimah Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Islam Indonesia, Jl. Kaliurang Km 14, Yogyakarta 55584, Indonesia

DOI:

https://doi.org/10.11113/jurnalteknologi.v86.20213

Keywords:

Aedes aegypti; gam gellan, pektin, nanopembawa magnetic, sinamaldehid

Abstract

Magnetic nanoparticles have evolved over the last few decades as nanocarriers in drug delivery systems for hydrophobic drugs. Here, novel gellan gum magnetic graphene oxide (GG-GO-Fe₃O₄) and pectin magnetic graphene oxide (PEC-GO-Fe₃O₄) nanocomposites were prepared to carry cinnamaldehyde to control Aedes aegypti larvae. Fourier transform infrared (FTIR) spectroscopy, field emission scanning electron microscopy (FESEM) and scanning transmission electron microscopy (STEM) were employed to investigate the physicochemical characteristics of the nanocomposites. Entrapment efficiencies and loading capacities of nanocomposites on cinnamaldehyde were examined using ultraviolet-visible analysis. The successful cinnamaldehyde loading was confirmed by C-C and C-O stretches in the FTIR spectra. Results of in vitro release study showed the capabilities of GG-GO-Fe₃O₄ as a drug carrier system, extending the cinnamaldehyde release period for 36 h, and the release profiles for both nanocomposites fit the Korsmeyer-Peppas kinetic model with correlation coefficient (R²) values of over 0.9809. The cinnamaldehyde-loaded GG-GO-Fe₃O₄ nanocomposites induced 68% mortality after 72 h of exposure, with LC₅₀ values ranging from 2.0488 and 15.9121 mg/L. The conjugation of GO-Fe₃O₄ with biopolymers improved the water solubility of cinnamaldehyde by 36.41 to 62.83 times vs. free cinnamaldehyde in water (1.42 mg/mL). Overall, these results are beneficial for researchers dealing with mosquito control and prevention.

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