A METALLURGICAL OVERVIEW OF TI – BASED ALLOY IN BIOMEDICAL APPLICATIONS
DOI:
https://doi.org/10.11113/jt.v76.5713Keywords:
Powder metallurgy (PM), vacuum arc melting (VAM), Ti CP, Ti-6Al-4V, impurity contentsAbstract
Titanium (Ti)-based alloys are prominently used in biomedical application. This review paper emphasizes on some of the important aspects of the Ti-alloys in terms of metallurgical aspects, manufacturing routes and biocompatibility. Two kinds of structure are reviewed namely dense and porous, both differs in terms of purpose and satisfies different needs. This advancement of materials and equipment helps to improve the quality of life for patients and alleviate their health problems. Metallic materials, mainly Ti-based alloys have been used commercially as bone implant owing to its promising mechanical properties, biocompatibility and bioactivity. The outmost important issue in manufacturing of this alloy is the impurity contents, specifically oxygen and carbon which contribute  to decreasing in material performance of the alloy attributed from the formation of unwanted oxide compounds such as TiO2 and TiC. Another issue is the mismatch value of the Young’s modulus between the metallic implant and bone that result in stress shielding effect. The structure of Ti-based alloy is mainly comprised of α-phase, β-phase or a combination of both that result in variation of Young’s modulus ranging from 45 -110 GPa. Compared to α-phase Ti alloy, the β-phase rich alloys may exhibit lower value of Young modulus through the right processing technique. Therefore, the development of β-phase Ti-alloys has been researched progressively in line with the need of low Young’s modulus that suit for implant applications.
References
Krishna, B. V., Bose, S. and Bandyopadhyay, A. 2007. Low Stiffness Porous Ti Structures For Load-Bearing Implants. Acta Biomaterials. 3(6) : 997–1006.
Manivasagam, G., Dhinasekaran, D. and Rajamanickam, A. 2010. Biomedical Implants: Corrosion and its Prevention - A Review. Recent Patents Corros. Sci. 2(i): 40–54.
Hon, Y. H, Wang, J. Y. and Pan,Y. N. 2003. Composition/Phase Structure and Properties of Titanium-Niobium Alloys. Mater. Trans. 44(11): 2384–2390.
Lefebvre, L. P., Banhart, J. and Dunand, D. C. 2008. Porous Metals And Metallic Foams: Current Status And Recent Developments. Adv. Eng. Mater. 10(9): 775–787.
Narayan, R. 2009. Biomedical materials, Springer.
Shah, C., Dave, R., Shah, M. and Dave, D. 2014. Evaluation Of Scalpel Versus Diode Laser For Gingival Depigmentation : A Case Report. (1): 24–27.
Pelaez-Vargas, A., Gallego-Perez, D., Higuita-Castro, N., Carvalho, A., Grenho, L., Arismendi, J. A., Fernandes, M. H, Ferraz, M. P., Hansford, D. J., and Monteiro, F. J., ,2012 Micropatterned Coatings For Guided Tissue Regenaration In Dental Implantology In Cell Interaction. Sivakumar G., InTech.
Li X., Luo Y., Wang C., Zhang W., and Li Y. 2012, Fabrication And In Vivo Evaluation Of Ti6Al4V Implants With Controlled Porous Structure And Complex Shape. Front. Mech. Eng. 7(1) : 66–71.
Wingrove Susan S., 2013 Peri-Implant Therapy for the Dental Hygienist: Clinical Guide to Maintenance and Disease Complications. John Wiley & Sons.
Oldani, C. and Dominguez, A., 2012, Titanium as a Biomaterial for Implants in Recent Advances in Arthroplasty. Fokter S. InTech.
Niinomi, M., 2002, Recent Metallic Materials For Biomedical Applications, Metall. Mater. Trans. A. 33: 477–486.
Niinomi, M., 2008, Metallic Biomaterials. J Artif Organs. 11: 106–110.
Okazaki, Y., Ohota, M., Ito, Y., and Tateishi, T., 1995, Corrosion Resistance Of Implant Alloys In Pseudo Physiological Solution And Role Of Alloying Elements In Passive Films. Nippon Kinzoku Gakkaishi/Journal of the Japan Institute of Metals. 59: 229–236,.
Niinomi M., 2003. Recent Research And Development In Titanium Alloys For Biomedical Applications And Healthcare Goods. Sci. Technol. Adv. Mater. 4: 445–454.
Gepreel, M. A.-H. and Niinomi, M., 2013, Biocompatibility Of Ti-Alloys For Long-Term Implantation. Journal of the Mechanical Behavior of Biomedical Materials. 20: 407–415.
Zardiackas, L. D., Kraay M. J., and Freese, H. L. 2012. Titanium, Niobium, Zirconium and Tantalum for Medical and Surgical Applications. ASTM.
Froes, F. H. and Bomberger, H. B., 1985, The Beta Titanium Alloys. JOM. 37(7): 28–37.
Mantani, Y. and Tajima, M. 2006, Phase Transformation Of Quenched Α Martensite By Aging In Ti–Nb Alloys. Mater. Sci. Eng. A. 438–440 : 315–319.
Lee, Peter J.,Abridged, 1999. Metallurgy Of Ductile Alloy Superconductors. Wiley Encyclopedia of Electrical and Electronics Engineering. 21: 75-87.
Tal-Gutelmacher, E. and Eliezer, D. 2005. The Hydrogen Embrittlement Of Titanium-Based Alloys. Jom. 57: 46–49.
Sung, S., Han, B., and Kim, Y. 2012. Formation of Alpha Case Mechanism on Titanium Investment Cast Parts. Titanium Alloys - Towards Achieving Enhanced Properties for Diversified Applications. Amin Nurul, InTech.
Razali, R., Abdullah, Z., Subuki, I., Ismail, M. H. and Muhamad, N. 2014, Feedstock Characterization of Elemental Nickel and Titanium Powders Mixture for Metal Injection Moulding Process. Appl. Mech. Mater.575: 78.
Sidambe, A. 2014. Biocompatibility of Advanced Manufactured Titanium Implants—A Review, Materials (Basel). 7(12): 8168–8188.
Nickels, L. 2012. World’s First Patient-Specific Jaw Implant. Met. Powder Rep. 67(2): 12–14.
Donaruma, L. G. 1988. Definitions In Biomaterials. J. Polym. Sci. Polym. Lett.26(9) : 414–414.
Kim, H. Y., Ikehara, Y., Kim, J. I., Hosoda, H., and Miyazaki, S. 2006. Martensitic Transformation Shape Memory Effect And Superelasticity Of Ti-Nb Binary Alloys. Acta Mater. 54: 2419–2429.
Thomas, P., Braathen, L. R. , Dörig, M., Aubock, J., Nestle, F., Werfel, T. and Willert, H. G. 2009. Increased Metal Allergy In Patients With Failed Metal-On-Metal Hip Arthroplasty And Peri-Implant T-Lymphocytic Inflammation. Allergy Eur. J. Allergy Clin. Immunol. 64(8): 1157–1165.
Kuroda, D. , Niinomi, M. , Morinaga, M. , Kato, Y. and Yashiro, T. 1998. Design And Mechanical Properties Of New Β Type Titanium Alloys For Implant Materials. Mater. Sci. Eng. A. 243(1–2): 244–249
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