THE DEGRADATION TEST OF IBS (INJECTABLE BONE SUBSTITUTES) PASTE SCAFFOLD USING EIS (ELECTRICAL IMPEDANCE SPECTROSCOPY) METHODS

Authors

  • Inas Amira Magister of Biomedical Engineering, Airlangga University, Surabaya, Indonesia
  • Dyah Hikmawati Physics, Airlangga University, Surabaya, Indonesia
  • Kamilia Kamilia Physics, Airlangga University, Surabaya, Indonesia
  • Khusnul Ain Biomedical Engineering, Airlangga University, Surabaya, Indonesia
  • Ade Agung Harnawan Physics, Lambung Mangkurat University, Banjarmasin, Indoensia
  • Bayu Ariwanto Magister of Biomedical Engineering, Airlangga University, Surabaya, Indonesia
  • Inten Firdausi Wardhan Biomedical Engineering, Airlangga University, Surabaya, Indonesia
  • Suprijanto Suprijanto Engineering Physics, Institute Technology Bandung, Bandung, Indoensia
  • Sari Ayu Wulandari Biomedical Engineering, Dian Nuswantoro University, Semarang, Indonesia
  • Hesty Susanti Biomedical Engineering, Telkom University, Bandung, Indonesia
  • Andi Besse Firdausiah Mansur Faculty of Computing and Information Technology in Rabigh, King Abdulaziz University, Rabigh 21911, Saudi Arabia
  • Ahmad Hoirul Basori Faculty of Computing and Information Technology in Rabigh, King Abdulaziz University, Rabigh 21911, Saudi Arabia

DOI:

https://doi.org/10.11113/jurnalteknologi.v88.23560

Keywords:

Injectable Bone Substitute, paste scaffold, Electrical Impedance, Spectroscopy, Degradation test

Abstract

There have been numerous cases of tuberculosis bone disease requiring immediate treatment. Efforts to treat the infection include drug delivery using IBS paste containing streptomycin and monitoring drug degradation. Various kinds of degradation tests have been common practice. However, real time monitoring weight change and loss of IBS is still needed to be explored. In this study, the material degradation along with drug release was detected using electrical impedance spectroscopy (EIS), which then compared with UV-VIS analysis. Degradation tests were performed on five samples of 800 μm pore size PLA scaffolds which has been injected IBS paste, using different immersion times. The IBS paste synthesis was prepared with a ratio of 65:45 hydroxyapatite to gelatin. The IBS paste was then injected into the scaffold, followed by degradation testing within five weeks. Finally, the degradation results of the IBS paste-infused scaffolds were measured using EIS. The test characterization included microscopic evaluation, degradation evaluation of the IBS paste-infused scaffolds, UV-VIS analysis and EISand. The microscope showed that the pore size before IBS paste injection ranged from 782.30 μm to 805.00 μm, while after IBS paste injection it ranged from 148.00 μm to 189.00 μm. The degradation test showed that the mass reduction of the IBS paste-infused scaffolds was influenced by the immersion time. UV-Vis showed a positive upward trend in the concentration of released IBS paste from 1 to 5 weeks, ranging from 1.168% to 2.522%. 

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Published

2025-12-23

Issue

Vol. 88 No. 1: January 2026

Section

Science and Engineering

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